Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction

Chen, Yan; Lu, Na; Ling, Yun; Gao, Ying; Wang, Ling; Sun, Yu; Qi, Qi; Feng, Feng; Liu, Wenyuan; Liu, Wei; Qin, You; Guo, Qinglong

doi:10.1016/j.tox.2009.01.010

Cited by 57 publications

(33 citation statements)

References 34 publications

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“…It also participates in cell cycle arrest and differentiation by regulating the expression and subcellular localization of PLSCR1 in AMl cells (20). Moreover, wogonoside induces the inhibition of lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction (21). The present study confirmed that wogonoside possesses the ability to induce cycle arrest and apoptosis in HCC cells, indicating that the glucuronide metabolite wogonoside, like its aglycone wogonin, possesses biological activity.…”

Section: Discussionsupporting

confidence: 77%

“…The anticancer effect of Scutellaria baicalensis extract has recently become a topic of interest. Moreover, a number of in vitro studies suggest that the extract of Scutellaria baicalensis inhibits the growth of various cancer cell lines through specific biological signaling pathways, including apoptosis, angiogenesis and inhibition of the androgen receptor (15,16,(18)(19)(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

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Wogonoside induces apoptosis in Bel-7402, a hepatocellular carcinoma cell line, by regulating Bax/Bcl-2

Chen

et al. 2015

Oncology Letters

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Abstract. The anticancer effect of Scutellaria baicalensis extract has recently become a topic of interest. In this study, the anticancer effects and underlying mechanisms of wogonoside, the main constituent of Scutellaria baicalensis, were investigated in a human hepatocellular carcinoma (HCC) cell line in vitro. The effects of wogonoside on the proliferation, cell cycle progression and apoptosis of hepatocellular carcinoma cells were examined. Western blotting was employed to analyze the proteins associated with the biological effects of wogonoside. Wogonoside exerted anti-proliferation properties in vitro. HCC cell growth was attenuated by wogonoside (8 µM) treatment. Cell cycle progression analysis and DNA ladder assay revealed that apoptosis was enhanced in wogonoside-treated cells and that cell cycle arrest occurred in the G2/M phase. It was also demonstrated that increased apoptosis was accompanied by increased levels of Bax protein and decreased levels of Bcl-2 protein. The results of this study suggest that wogonoside may represent a potential therapeutic agent against HCC.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Wogonoside induces apoptosis in Bel-7402, a hepatocellular carcinoma cell line, by regulating Bax/Bcl-2

Chen

et al. 2015

Oncology Letters

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“…It inhibits HIV-1 infection and replication by inhibiting HIV-1 reverse transcriptase (Kitamura et al 1998). Wogonoside inhibits lipopolysaccharide-induced angiogenesis (Chen et al 2009). It demonstrates strong activity against lipid peroxidation and an inhibitory effect on histamine and IgE production (Lim 2003).…”

Section: Introductionmentioning

confidence: 99%

The effect of cytokinins on shoot proliferation, secondary metabolite production and antioxidant potential in shoot cultures of Scutellaria alpina

Grzegorczyk-Karolak

Kuźma

Wysokińska

2015

Plant Cell Tiss Organ Cult

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The present study evaluates the effects of various cytokinins on Scutellaria alpina shoot proliferation and production of polyphenolic metabolites (baicalin, wogonoside, luteolin, luteolin 7-O-glucoside, verbascoside). The shoots were induced from shoot tips on MS medium supplemented with IAA (indole-3-acetic acid, 0.57 lM) and various concentrations of 6-benzylaminopurine (BAP), kinetin, zeatin (1, 2, 4, 8 lM) or tidiazuron (TDZ) (0.2, 0.5, 1 lM). Among the cytokinins tested, BAP was the most effective for shoot induction, and the highest number of shoots (25 per explant) was achieved with 2 and 4 lM BAP. Maximum biomass production was also achieved on these media. Significantly higher baicalin, wogonoside and verbascoside contents were recorded in treatments containing cytokinins combined with 0.57 lM IAA, when compared to cytokinin-free medium. TDZ at a concentration of 0.5 lM was the most effective for polyphenol production. However, supplementation with cytokinins often results in the reduction of luteolin and its 7-O-glucoside production in the shoot culture of S. alpina. ABTS [2,20 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)] and ferric reducing antioxidant power assays were used to identify the antioxidant potential of methanolic extracts from shoots cultured in the presence of different types and concentrations of cytokinins. In both tests, the shoots from medium supplemented with 0.5 lM TDZ demonstrated the strongest antioxidant activity. The results indicate that higher polyphenolic content correlated with greater reducing power and antiradical efficiency.

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“…Wogonine is isolated from the chinese herb Scutellaria baicalensis Georgi, a flowering plant of the Lamiaceae family. It has been demonstrated that wogonine and its metabolite wogonoside have antioxidant and anti-inflammatory effects [74]; moreover wogonine induce cell cycle arrest, apoptosis and differentiation not only on different cancer cell lines [75], but also in hematologic malignancies where it induces apoptosis on malignant lymphocytes and suppresses cell growth of T-cells. Besides, wogonoside affects differentiation, acting on human AML cells in vitro and in vivo.…”

Section: Differentiation Inducers In Aml and CMLmentioning

confidence: 99%

Natural Compounds: Molecular Weapons against Leukemia’s

Taverna¹,

Corrado

2017

J Leuk

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Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones.A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis.Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.

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Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction

Cited by 57 publications

References 34 publications

Wogonoside induces apoptosis in Bel-7402, a hepatocellular carcinoma cell line, by regulating Bax/Bcl-2

Wogonoside induces apoptosis in Bel-7402, a hepatocellular carcinoma cell line, by regulating Bax/Bcl-2

The effect of cytokinins on shoot proliferation, secondary metabolite production and antioxidant potential in shoot cultures of Scutellaria alpina

Natural Compounds: Molecular Weapons against Leukemia’s

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