Wolfberry (Lycium barbarum) Consumption with a Healthy Dietary Pattern Lowers Oxidative Stress in Middle-Aged and Older Adults: A Randomized Controlled Trial

Toh, Darel Wee Kiat; Lee, Wan Yee; Zhou, Hanzhang; Sutanto, Clarinda; Lee, Delia Pei Shan; Tan, Denise; Kim, Jung Eun

doi:10.3390/antiox10040567

Cited by 17 publications

(9 citation statements)

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“…Wolfberry (Lycium barbarum L., 2n = 2x = 24), of the genus Lycium within the Solanaceae family, is an important Chinese traditional herbal medicine [1]. The fruits are a rich source of carotenoids, flavonoids, and polysaccharides, contributing to wolfberry's immuneenhancing, antioxidant, and anti-tumor effects [2][3][4]. The carotenoids are responsible for L. barbarum fruit colorations [5,6].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Comparative Analysis of the R2R3-MYB Gene Family in Five Solanaceae Species and Identification of Members Regulating Carotenoid Biosynthesis in Wolfberry

Yin

Guo

Shi

et al. 2022

IJMS

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The R2R3-MYB is a large gene family involved in various plant functions, including carotenoid biosynthesis. However, this gene family lacks a comprehensive analysis in wolfberry (Lycium barbarum L.) and other Solanaceae species. The recent sequencing of the wolfberry genome provides an opportunity for investigating the organization and evolutionary characteristics of R2R3-MYB genes in wolfberry and other Solanaceae species. A total of 610 R2R3-MYB genes were identified in five Solanaceae species, including 137 in wolfberry. The LbaR2R3-MYB genes were grouped into 31 subgroups based on phylogenetic analysis, conserved gene structures, and motif composition. Five groups only of Solanaceae R2R3-MYB genes were functionally divergent during evolution. Dispersed and whole duplication events are critical for expanding the R2R3-MYB gene family. There were 287 orthologous gene pairs between wolfberry and the other four selected Solanaceae species. RNA-seq analysis identified the expression level of LbaR2R3-MYB differential gene expression (DEGs) and carotenoid biosynthesis genes (CBGs) in fruit development stages. The highly expressed LbaR2R3-MYB genes are co-expressed with CBGs during fruit development. A quantitative Real-Time (qRT)-PCR verified seven selected candidate genes. Thus, Lba11g0183 and Lba02g01219 are candidate genes regulating carotenoid biosynthesis in wolfberry. This study elucidates the evolution and function of R2R3-MYB genes in wolfberry and the four Solanaceae species.

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Section: Introductionmentioning

confidence: 99%

Genome-Wide Comparative Analysis of the R2R3-MYB Gene Family in Five Solanaceae Species and Identification of Members Regulating Carotenoid Biosynthesis in Wolfberry

Yin

Guo

Shi

et al. 2022

IJMS

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“…Associations between the plasma lipidomic changes and the corresponding effects on a panel of CVD-related risk indicators ( n = 47) and nutrition/dietary information ( n = 35) were studied ( 20 , 21 ). Main effects (i.e., between lipid species and outcome of interest) are summarized in heat maps ( Supplementary Figure 4 ) with the main effect size and Q values of significant pairs additionally detailed in Supplementary Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…This is supported by wolfberry-based clinical trials which reported favorable changes to blood lipid-lipoproteins following a 3 months intervention with L. barbarum polysaccharides (100 mg/kg body weight daily) and a 45-day intervention with whole wolfberry (14 g dried fruit per day) ( 17 – 19 ). Previously, we demonstrated notable improvements in HDL cholesterol (HDL-C) concentration ( 20 ) and oxidative stress status ( 21 ) following the consumption of 15 g/day whole wolfberry with a HDP for 16 weeks. Nevertheless, limited studies examined these blood lipid changes in detail and the potential mechanisms that underlie the observed cardiovascular protective benefits.…”

Section: Introductionmentioning

confidence: 99%

Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults

Toh,

Zhou,

Cazenave-Gassiot

et al. 2024

Front. Nutr.

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BackgroundLong-term wolfberry intake as part of a healthy dietary pattern was recognized to have beneficial vascular outcomes. Characterization of the plasma lipidome may further provide comprehensive insights into pathways underlying these cardiovascular protective effects.ObjectiveWe analyzed the plasma lipidome of subjects who adhered to a healthy dietary pattern either with or without wolfberry and investigated the associations between the plasma lipidomic profile and cardiovascular health-related indicators.MethodsIn this 16-week, parallel design, randomized controlled trial, middle-aged and older adults (n = 41) were provided dietary counseling and assigned to either consume or not consume 15 g of wolfberry daily. At baseline and post-intervention, plasma lipidomics was assayed, and its relationships with classical CVD risk factors, vascular health, oxidant burden, carotenoids status, body composition, and anthropometry were examined.ResultsFrom the plasma lipidome, 427 lipid species from 26 sub-classes were quantified. In the wolfberry and control groups, significant changes were prominent for 27 and 42 lipid species, respectively (P < 0.05 with > 0.2-fold change). Fold changes for seven lipid species were also markedly different between the two groups. Examining the relationships between the plasma lipidome and CVD-related risk factors, total cholesterol revealed a marked positive correlation with 13 ceramide species, while HDL-cholesterol which was notably increased with wolfberry consumption showed a positive correlation with 10 phosphatidylcholine species. Oxidant burden, as represented by plasma 8-isoprostanes, was also inversely associated with lipidomic triglycerides and ether-triglycerides (41 species) and directly associated with hexosylceramides (eight species) and sphingomyelins (six species). There were no differential associations with CVD risk detected between groups.ConclusionCharacteristic alterations to the plasma lipidome were observed with healthy dietary pattern adherence and wolfberry consumption. An examination of these fluctuations suggests potential biochemical mechanisms that may mediate the antioxidant and cardiovascular protective effects of healthy dietary pattern adherence and wolfberry intake. This study was registered at clinicaltrials.gov as NCT0353584.

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“…In addition, they observed an inverse association between the changes in plasma zeaxanthin and plasma 8-iso-prostaglandin F2α. Therefore, goji berry within a healthy dietary pattern is proposed as a dietary strategy to attenuate lipid peroxidation among middle-aged and older adults, with a heightened risk of oxidative stress-induced age-related disorders [ 95 ].…”

Section: Health Benefits and Side Effects Of Goji Berry Consumptionmentioning

confidence: 99%

Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review

et al. 2022

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Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due to wide-range bioactive compounds with health-promoting properties. In addition, they are gaining increased research attention as a source of functional ingredients with potential industrial applications. This review focuses on the antioxidant properties of goji berries, scientific evidence on their health effects based on human interventional studies, safety concerns, goji berry processing technologies, and applications of goji berry-based ingredients in developing functional food products.

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Wolfberry (Lycium barbarum) Consumption with a Healthy Dietary Pattern Lowers Oxidative Stress in Middle-Aged and Older Adults: A Randomized Controlled Trial

Cited by 17 publications

References 58 publications

Genome-Wide Comparative Analysis of the R2R3-MYB Gene Family in Five Solanaceae Species and Identification of Members Regulating Carotenoid Biosynthesis in Wolfberry

Genome-Wide Comparative Analysis of the R2R3-MYB Gene Family in Five Solanaceae Species and Identification of Members Regulating Carotenoid Biosynthesis in Wolfberry

Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults

Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review

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