Women and Men with Hypercholesterolemia Respond Similarly to an American Heart Association Step 1 Diet

Geil, Patti; Anderson, James W.; Gustafson, N J

doi:10.1016/s0002-8223(95)00118-2

Cited by 34 publications

(15 citation statements)

References 43 publications

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“…This was confirmed by comparing their self-reported physical activity at baseline and follow up. Similar results were also shown in other studies that used only dietary intervention (Geil et al, 1995;Aldana et al, 2002). Improvement in ratios of total serum cholesterol to HDL-cholesterol was observed in studies combining dietary and physical fitness intervention (Angotti and Levine, 1994;Lalonde et al, 2002).…”

Section: Discussionsupporting

confidence: 88%

The results of a worksite health promotion programme in Kuala Lumpur, Malaysia

Moy

Sallam

Wong

2006

Health Promotion International

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SUMMARYThe worksite is one of the key channels for the delivery of interventions to reduce chronic diseases among adult populations. It provides easy and regular access to a relatively stable population and it encourages sustained peer support. This paper reports a 2-year follow-up of the impact of a worksite health promotion programme on serum cholesterol and dietary changes among employees in a city in Malaysia. A quasi-experimental study was conducted among Malay-Muslim male security guards, with those working in a public university in Kuala Lumpur comprising the intervention group, and those working in the teaching hospital of the same university as the comparison group. They were comparable in sociodemographic characteristics. The intervention group received intensive individual and group counselling on diet, physical activity and quitting smoking. The comparison group was given minimal education on the same lifestyle changes through mail and group counselling. The intervention group showed a statistically significant reduction in their mean total cholesterol levels as compared with the comparison group, with an intervention effect of -0.38 (95% CI = -0.63, -0.14) mmol/l. The intervention group also reported a reduction in the amount of cigarettes smoked. The worksite was shown to be an effective channel for health promotion. The adoption of the new lifestyle behaviours should be supported and sustained through modification of work policies.

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Section: Discussionsupporting

confidence: 88%

The results of a worksite health promotion programme in Kuala Lumpur, Malaysia

Moy

Sallam

Wong

2006

Health Promotion International

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“…Among women, HDL-C underwent the greater change so that the LDL-C:HDL-C ratio in men remained higher than in women. However, Geil et al (1995) found that both men and women responded similarly to a fat-reduced diet. In this context, the failure of isolated isoflavones, from both soy and red clover, to lower LDL-C might be viewed as being partly due to the predominance of women in these studies.…”

Section: Discussionmentioning

confidence: 93%

A biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men

et al. 2004

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Objective: To determine whether the two major isoflavones in red clover differ in their effect on low-density lipoprotein cholesterol (LDL-C). Design: A randomised, placebo-controlled, double-blind trial; two parallel groups taking one of the two isoflavones within which treatment and placebo were administered in a crossover design. Setting: Free-living volunteers. Subjects: A total of 46 middle-aged men and 34 postmenopausal women. Intervention: Two mixtures of red clover isoflavones enriched in either biochanin (n ¼ 40) or formononetin (n ¼ 40) were compared. Placebo and active treatment (40 mg/day) were administered for 6 weeks each in a crossover design within the two parallel groups. Main outcome measures: Plasma lipids were measured twice at the end of each period. Results: Baseline LDL-C concentrations did not differ significantly between men (n ¼ 46) and women (n ¼ 34), nor between those randomised to biochanin or formononetin. Interaction between time and treatments, biochanin, formononetin and corresponding placebos (two-way ANOVA) on LDL-C showed a significant effect of biochanin treatment alone. The biochanin effect was confined to men; median LDL-C was 3.61 (3.05-4.14) mmol/l with biochanin and 3.99 (3.16-4.29) mmol/l with the corresponding placebo (RM ANOVA with Dunnett's adjustment Po0.05). The difference between placebo and biochanin effects on LDL-C was 9.5%. No other lipid was affected and women failed to respond significantly to treatment. Conclusion: Isolated isoflavones from red clover enriched in biochanin (genistein precursor) but not in formononetin (daidzein precursor), lowered LDL-C in men. This may partly explain the previous failure to demonstrate cholesterol-lowering effects with mixed isoflavones studied predominantly in women.

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“…At 12 months, reductions were 4.9% and 3.7%, respectively, in women with HC and CHL, and 4.9% and 5.2% in men with HC and CHL, respectively. Similarly, no gender difference was observed in LDL cholesterol lowering with counseled dietary intervention in the study by Geil et al [33] (Step I diet) and in the counseled dietary interventions of Mensinck and Katan [31,32] (low saturated fat diet with supplemental mono-and polyunsaturates).…”

Section: Dietary Effects On Low-density Lipoproteinmentioning

confidence: 84%

Gender differences in lipoprotein metabolism and dietary response: Basis in hormonal differences and implications for cardiovascular disease

Knopp

Paramsothy²,

Retzlaff³

et al. 2005

Curr Atheroscler Rep

126

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The transport of fat in the blood stream is approximately twice as fast in women as men. Disease states such as obesity and diabetes are associated with greater lipoprotein abnormalities in women compared with men. A greater increment in cardiovascular disease risk in women is linked to these abnormalities. A greater change in triglyceride level and a lesser change in low-density lipoprotein are observed in women than men with high-carbohydrate or high-fat feeding. Most consistent are greater changes in high-density lipoprotein (HDL), HDL2, and apolipoprotein A-I levels in women compared with men with high-carbohydrate or high-fat feeding. Dietary fat restriction in women appears to have a less beneficial lipoprotein effect than in men. Dietary fat restriction for heart disease prevention may be less ideal in women than in men.

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Women and Men with Hypercholesterolemia Respond Similarly to an American Heart Association Step 1 Diet

Cited by 34 publications

References 43 publications

The results of a worksite health promotion programme in Kuala Lumpur, Malaysia

The results of a worksite health promotion programme in Kuala Lumpur, Malaysia

A biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men

Gender differences in lipoprotein metabolism and dietary response: Basis in hormonal differences and implications for cardiovascular disease

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