“…Sodium phosphate is another legal, nutritional supplement where the ingestion of~4 g or 50 mg • kg −1 fat free mass (FFM) per day for 3-6 days has been reported to improve endurance exercise performance (Brewer, Dawson, Wallman, & Guelfi, 2013;Kreider et al, 1992;Kreider, Miller, Williams, Somma, & Nasser, 1990) and aerobic capacity (Brewer, Dawson, Wallman, & Guelfi, 2014;Cade et al, 1984;Czuba, Zajac, Poprzecki, Cholewa, & Woska, 2009;Kreider et al, 1992), with other studies finding no benefit (Buck, Wallman, Dawson, McNaughton, & Guelfi, 2014;West, Ayton, Wallman, & Guelfi, 2012). Numerous mechanisms have been proposed to provide benefit to exercise performance following sodium phosphate loading, with these including enhanced 2,3-diphosphoglycerate (2,3-DPG) concentration in red blood cells, which allows for a greater unloading of oxygen to the peripheral tissues (Benesch & Benesch, 1969); improved buffering capacity of hydrogen ions due to increased hydrogen phosphate concentrations (Kreider, 1999); improved myocardial efficiency, which results in more efficient oxygenation of exercising muscles (Kreider et al, 1992); greater ATP/PCr synthesis due to increased availability of extracellular and intracellular phosphate (Bredle, Stager, Brechue, & Farber, 1988;Kreider, 1999); and enhanced activation of rate-limiting constituents of the glycolytic and Krebs cycles (Kreider et al, 1992).…”