Women gain weight and fat mass despite lipectomy at abdominoplasty and breast reduction

Rinomhota, A S; Bulugahapitiya, D U S; French, Stephen; Caddy, Christopher M.; Griffiths, Richard W.; Ross, Robert

doi:10.1530/eje-07-0852

Cited by 18 publications

(15 citation statements)

References 19 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, Rinomhota et al73 reported greater weight and body fat regain in subjects with a higher presurgery weight at 18 months after a large-volume liposuction plus abdominoplasty surgery. Experimental studies seem to support this hypothesis.…”

Section: Liposuctionmentioning

confidence: 99%

“…Nonetheless, the few studies that have made this attempt show controversial results. Rinomhota et al73 observed a substantial increase in body weight (+5%–6% of the pre-surgery weight) and total body fat (+16% of the presurgery fat mass) in overweight to obese women 18 months after a large-volume liposuction plus abdominoplasty surgery. In contrast, 2 months after abdominal liposuction or abdominoplasty in seven nonobese women, Lambert et al74 reported no changes in the regional fat distribution in nonoperated areas or in the fat cell size in femoral (nonoperated area) and abdominal regions (operated area).…”

Section: Liposuctionmentioning

confidence: 99%

“…It has been affirmed that presurgery body fat is an important factor in determining weight and fat gain following surgery and that overweight and obese individuals are more prone to the recovery of body fat than eutrophic people,68,73 although to our knowledge no studies have directly addressed this issue. Nevertheless, Rinomhota et al73 reported greater weight and body fat regain in subjects with a higher presurgery weight at 18 months after a large-volume liposuction plus abdominoplasty surgery.…”

Section: Liposuctionmentioning

confidence: 99%

See 2 more Smart Citations

Strategies for reducing body fat mass: effects of liposuction and exercise on cardiovascular risk factors and adiposity

Benatti

Lira²,

Oyama³

et al. 2011

DMSO

View full text Add to dashboard Cite

Liposuction is the most popular aesthetic surgery performed in Brazil and worldwide. Evidence showing that adipose tissue is a metabolically active tissue has led to the suggestion that liposuction could be a viable method for improving metabolic profile through the immediate loss of adipose tissue. However, the immediate liposuction-induced increase in the proportion of visceral to subcutaneous adipose tissue could be detrimental to metabolism, because a high proportion of visceral to subcutaneous adipose tissue is associated with risk factors for cardiovascular disease. The results of studies investigating the effects of liposuction on the metabolic profile are inconsistent, however, with most studies reporting either no change or improvements in one or more cardiovascular risk factors. In addition, animal studies have demonstrated a compensatory growth of intact adipose tissue in response to lipectomy, although studies with humans have reported inconsistent results. Exercise training improves insulin sensitivity, inflammatory balance, lipid oxidation, and adipose tissue distribution; increases or preserves the fat-free mass; and increases total energy expenditure. Thus, liposuction and exercise appear to directly affect metabolism in similar ways, which suggests a possible interaction between these two strategies. To our knowledge, no studies have reported the associated effects of liposuction and exercise in humans. Nonetheless, one could suggest that exercise training associated with liposuction could attenuate or even block the possible compensatory fat deposition in intact depots or regrowth of the fat mass and exert an additive or even a synergistic effect to liposuction on improving insulin sensitivity and the inflammatory balance, resulting in an improvement of cardiovascular risk factors. Consequently, one could suggest that liposuction and exercise appear to be safe and effective strategies for either the treatment of metabolic disorders or aesthetic purposes.

show abstract

Section: Liposuctionmentioning

confidence: 99%

Section: Liposuctionmentioning

confidence: 99%

Section: Liposuctionmentioning

confidence: 99%

See 1 more Smart Citation

Strategies for reducing body fat mass: effects of liposuction and exercise on cardiovascular risk factors and adiposity

Benatti

Lira²,

Oyama³

et al. 2011

DMSO

View full text Add to dashboard Cite

show abstract

“…Current pharmacologic or dietary therapies aimed at the reduction of obesity do not discriminate between subcutaneous and visceral adipose depots and are ineffective, especially in aging and disabled patients. Another critical shortcoming of these approaches is the poor compliance of patients to these regimens with inevitable attrition of therapeutic efficacy even after invasive bariatric and liposuction/lipectomy [21,22]. In the absence of effective treatment, obesity rates are increasing in epidemic proportions worldwide with 65 million more obese adults expected in the US alone by the year 2030 [23].…”

Section: Introductionmentioning

confidence: 99%

The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-l-lysine

Yang

Zhang²,

Maiseyeu

et al. 2012

Biomaterials

View full text Add to dashboard Cite

Although alginate-poly-L-lysine (APL) encapsulation of cells producing bioactive peptides has been widely tested, it is unknown whether APL supports lasting catabolic functions of encapsulated cells in adipose tissue, which are required for obesity reduction. We tested functions of APL-encapsulated fibroblasts isolated from wild-type (WT) and aldehyde dehydrogenase 1a1 knockout mice (KO), which resist obesity on a high-fat (HF) diet, have a higher metabolic rate, and express increased levels of thermogenic uncoupling protein-1 (Ucp1) in their deleterious visceral fat depots compared to WT mice. To enable in vivo detection and quantification, fibroblasts were stably transfected with green-fluorescent protein. WT- or KO-containing microcapsules were injected into two visceral depots of WT mice fed an HF diet. Eighty days after transplantation, microcapsules were located in vivo using magnetic resonance imaging. KO microcapsules prevented weight gain in obese WT mice compared to a mock- and WT capsule-injected groups on an HF diet. The weight loss in KO-treated mice corresponded to lipid reduction and induction of thermogenesis in the injected visceral fat. The non-treated subcutaneous fat was not altered. Our data suggest that the APL polymer supports long-term catabolic functions of genetically-modified fibroblasts, which can be potentially used for depot-specific obesity treatment.

show abstract

“…Alguns autores sugerem que o peso corporal pré-cirúrgico seja um importante fator determinante do reposição de peso e gordura corporal após a cirurgia, e que indivíduos obesos estão mais propensos a recuperar a gordura removida do que indivíduos eutróficos (BUENO et al, 2005;RINOMHOTA et al, 2008). Ao nosso conhecimento, nenhum estudo até hoje avaliou diretamente esta hipótese.…”

Section: Efeitos Na Adiposidade E Na Distribuição De Gordura Corporalunclassified

Efeitos da lipoaspiração acompanhada de treinamento físico no perfil metabólico e na composição corporal de mulheres adultas eutróficas e saudáveis

Benatti¹

View full text Add to dashboard Cite

Junior, pelo constante incentivo e apoio ao longo da minha jornada acadêmica no Pós Graduação, e, principalmente, pela oportunidade e pela confiança depositada neste trabalho. Aos meus pais, Juliano e Rita, por sempre terem sido um modelo de perseverança, união e honestidade, por serem a minha fortaleza, pelo amor e confiança incondicionais, por estarem presentes em todos os momentos, sejam eles de tristezas ou de alegrias e conquistas, acima de tudo me apoiando com muito amor. Aos meus irmãos Fernanda e Bruno, por sempre estarem ao meu lado, por serem meus irmãos de sangue e de coração, por me apoiarem sempre e incondicionalmente e, acima de tudo, por conseguirmos manter essa união inabalável, que me dá muita força e confiança. Ao Renê, meu companheiro maravilhoso, por todo o amor, carinho e paciência, por estar sempre ao meu lado, por ser capaz de me fazer sorrir com as coisas mais simples, de me amparar nas horas tristes e de angústia, e de me ajudar a manter meus "pés no chão", sempre me incentivando e me ajudando em todos os momentos. Á Marina, que de colega de laboratório virou uma das minhas grandes amigas ao longo deste estudo. Eu te agradeço de coração por toda a paciência, todo o seu esforço, apoio e amizade. Ao Eduardo Montag, profissional e pessoa incrível, pela confiança que tornou possível a realização deste trabalho, além de todo carinho, amizade e humor único, que fez das intermináveis cirurgias momentos muito divertidos. Aos médicos e auxiliares que participaram do estudo, Fábio Saito, Alberto Okada, Alexandre Teruya e Michele, por todo o esforço, boa vontade e confiança iii depositada. Em especial, à Carol Kitsis, profissional e pessoa fantástica, por toda a ajuda e amizade. Aos membros do laboratório, meus amigos de coração. Por todo o apoio, ajuda, conselhos e pelos inesquecíveis momentos ao longo de todos esses anos, em especial ao Guilherme, Bruno, Desire, Dani, Hamilton, André, Aline, Daisy, Ana, Serena, Chris, Pati Campos, Humberto e Fernando, além dos novos membros que agora chegam. Em especial ao Vitor, pela ajuda e pela capacidade única de superar os momentos obscuros e as tentações mundanas e proporcionar intermináveis momentos de risada histérica no laboratório. Ao amigos, família e primos, em especial aos meus cunhados Luciana e Sérgio e aos meus sogros Carmem e Geraldo, que moram no meu coração. Ao Instituto Vita, ao Uno Hospital Dia e ao LACRE, pela parceria, em especial à Fernanda Lima e à Ana Lúcia. Ao Miguel e ao Rodrigo Xavier, membros do Labotarório de Lípides do ICB-USP, por toda a ajuda. À Fapesp, pelo apoio financeiro. Aos funcionários da Secretaria de Pós-Graduação, Márcio e Ilza. À Shirley, secretária do Departamento de Biodinâmica, e à Rosângela, por toda a ajuda e paciência. Aos amigos da equipe de voleibol da EEFE-USP, pela amizade, por toda a torcida, e por muitos momentos divertidos durante esses anos.

show abstract

Women gain weight and fat mass despite lipectomy at abdominoplasty and breast reduction

Cited by 18 publications

References 19 publications

Strategies for reducing body fat mass: effects of liposuction and exercise on cardiovascular risk factors and adiposity

Strategies for reducing body fat mass: effects of liposuction and exercise on cardiovascular risk factors and adiposity

The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-l-lysine

Efeitos da lipoaspiração acompanhada de treinamento físico no perfil metabólico e na composição corporal de mulheres adultas eutróficas e saudáveis

Contact Info

Product

Resources

About