“…The management plan favors medical one, including physical rehabilitation, 28 whereas the percutaneous intervention remains debatable even in most experienced centers due to numerous short-and long-term complications, so the initially dreaded surgical unroofing gives the most promising and permanent solution. [39][40][41][42][43][44] Finally, as sex disparities in care remain the bane of cardiology worldwide and the current lack of sex differences in reports of MBs where men dominate, the logical question seems to be whether it is due to the traditional lack of inclusion of women as patients in trials and registries that continued despite the SARS-CoV2 pandemic 45 or is it truly a matter of pure genetic coup de chance that women are, indeed, less affected. Aiming to mitigate that role of fate and as the concept of heart centers for women has been promoted globally, 46,47 the Serbian group 48 has a dedicated clinic -within its women's heart program -for women diagnosed with an MB, among other coronary artery anomalies that endorse other "Dr. Nanette Kass Wenger" Women's Heart Center advocacy activities and helps build international registries aiming to fill the gap of sex-disparities in cardiovascular care.…”