Women in sports: The applicability of reference intervals for 6 commercially available testosterone immunoassays (HemSter Study)

Biljak, Vanja Radišić; Đuras, Anamarija; Čičak, Helena; Vidranski, Valentina; Vidranski, Tihomir; Peersman, Nele; Vermeersch, Pieter; Ostroški, Ivanka; Ružić, Lana; Šimundić, Ana Maria

doi:10.1016/j.clinbiochem.2020.06.006

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…A comparison of the basic demographic characteristics of the subjects was in line with the one already published in an article by Radišić Biljak et al (14). There were statistically significant differences in age (P = 0.046), weight (P < 0.001), height (P < 0.001), and body mass index (BMI) (P < 0.001) between female athletes across different sports, their quantitative measure of physical activity (MET) did not differ significantly among the groups (P = 0.226).…”

Section: Resultssupporting

confidence: 81%

“…As previously reported, female athletes enrolled in this study did differ in age, weight, height, and, consequently, BMI, even after excluding six athletes who were OC-users (14). However, the athletes did not differ in their quantitative measure of physical activity expressed in metabolic equivalent (MET).…”

Section: Discussionsupporting

confidence: 48%

“…One hundred and twenty-one young healthy female athletes, playing several most popular team sports (water polo, handball, volleyball, football, basketball) were included in the study. The study group was extensively described in a paper by Radišić Biljak et al (14). The information about their menstrual cycle and the usage of oral contraceptives (OC) was collected.…”

Section: Subjectsmentioning

confidence: 99%

“…To better understand how physical activity and subsequent changes in various biomarkers affect the applicability of general RIs in athletes, a large multicentre study entitled "Women in sports: applicability of available reference intervals (HemSter Study)" was launched in 2019. The study included four separate goals, one of which has already been successfully addressed (14). The aim of this study was to assess the applicability of the common national available RIs for common inflammatory and screening coagulation tests in a population of healthy young female athletes, in the fasting state, prior to any physical activity.…”

Section: Introductionmentioning

confidence: 99%

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Women in sports: the applicability of common national reference intervals for inflammatory and coagulation biomarkers (HemSter Study)

Biljak

Vidranski²,

Ružić

et al. 2021

Biochem. med. (Online)

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Introduction Intensive physical activity causes functional and metabolic changes in the athlete’s organism. The study aimed to verify the common national available reference intervals (RIs) for common inflammatory and screening coagulation tests in a population of healthy young female athletes. Materials and methods One hundred and twenty-one female athletes (age range: 16–34), from various sports disciplines (water polo, handball, volleyball, football, basketball), were included in the study. All participants completed the international physical activity short-form questionnaire. Blood samples were collected between 8–10 am, after an overnight fast, before any physical activity. Reference intervals were determined according to Clinical & Laboratory Standards Institute EP28-A3C Guidelines. Results Calculated RIs for white blood cell count (WBC), prothrombin time (PT), and activated partial thromboplastin time (APTT) ratio were in accordance with the common national RIs. Calculated RI for C-reactive protein (CRP) was lower (< 2.9 mg/L) than the proposed cut-off for a healthy population (< 5.0 mg/L). Reference interval for fibrinogen was higher (1.9–4.4 g/L), than the available RIs (1.8–3.5 g/L). D-dimer cut-off value was set at 852 µg/L fibrinogen equivalent units (FEU), higher than the proposed 500 µg/L FEU for venous thromboembolism (VTE) exclusion. Conclusions The applicability of the available RIs for WBC count, PT, and APTT-ratio was confirmed. However, RIs for CRP and fibrinogen differed significantly than the available common national RIs for the healthy non-athletes’ population. A higher cut-off for D-dimers should be extensively verified before implementation for VTE diagnosis exclusion in a group of healthy young female athletes.

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Section: Resultssupporting

confidence: 81%

Section: Discussionsupporting

confidence: 48%

Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Women in sports: the applicability of common national reference intervals for inflammatory and coagulation biomarkers (HemSter Study)

Biljak

Vidranski²,

Ružić

et al. 2021

Biochem. med. (Online)

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Preliminary evaluation of eight less frequent endocrine assays designed for MAGLUMI 800 chemiluminescence immunoanalyzer

Lapić

Oguić

Rogić

2021

Scandinavian Journal of Clinical and Laboratory Investigation

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Promising directions of laboratory diagnostics in spores and fitness

Zaharodny¹,

Sherash²,

Budko³

et al. 2021

jour

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The article describes the main biomarkers for determining human adaptation to physical activity. Analyzed modern scientific publications on the criteria of individual tolerance of food products, studied promising directions of personalized correction of the diet. The authors have formed a group of valid (sports-specific) laboratory indicators, it is proposed to pay close attention to the reference values of laboratory equipment that have “their own” norms. A promising direction of laboratory diagnostic work is the formation of reliable and accessible complementary criteria that are at the “junction” of functional and instrumental diagnostic methods. Metabolomics is viewed as a young but highly effective science for detecting highly specific metabolic characteristics of human health. The authors proposed the main directions of scientific research in laboratory diagnostics in sports.

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Women in sports: The applicability of reference intervals for 6 commercially available testosterone immunoassays (HemSter Study)

Cited by 3 publications

References 18 publications

Women in sports: the applicability of common national reference intervals for inflammatory and coagulation biomarkers (HemSter Study)

Women in sports: the applicability of common national reference intervals for inflammatory and coagulation biomarkers (HemSter Study)

Preliminary evaluation of eight less frequent endocrine assays designed for MAGLUMI 800 chemiluminescence immunoanalyzer

Promising directions of laboratory diagnostics in spores and fitness

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