I n this chapter, we explore who Native Americans are and how their history and current situations have defined their career and work opportunities. Using a developmental framework, we review the extant literature on career psychology and work in the Native American context in order to provide a foundation for further research and the construction of career counseling interventions.Approximately 2% (6.8 million) of the U.S. population identify as Native American (U.S. Census Bureau, 2018). There are currently 567 federally recognized tribes and 63 state-recognized tribes with which Native Americans identify (Bureau of Indian Affairs, n.d.;Salazar, 2016). About 22% of Native Americans live in tribal statistical areas and on Native American reservations, where there is significant poverty and unemployment. The other 78% live off reservation, with 72% living in urban and suburban areas, often in lower socioeconomic status neighborhoods (Urban Indian Health Institute, 2013; U.S. Census Bureau, 2012).Prior to European contact, during the pre-Columbian period, the number of Indigenous people inhabiting North America is estimated to have ranged from 5 million to 15 million (e.g., Fixico, 2020). By the 1600s, the lack of immunity to European-borne smallpox, measles, and other diseases had killed an estimated 90% of these populations (Koch et al., 2019). Over the next 150 years, there were more than 1,500 government-sanctioned attacks, wars, and raids, in which large numbers of Native Americans were also killed, so that by the 1890s only 240,000 Native Americans remained (Fixico, 2020).