Womenʼs experience of menopause: a systematic review of qualitative evidence

Hoga, Luíza Akiko Komura; Rodolpho, Juliana Reale Caçapava; Gonçalves, Bruna Goulart; Quirino, Bruna

doi:10.11124/01938924-201513080-00018

Cited by 87 publications

(41 citation statements)

References 64 publications

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“…For this reason, we focused on women with menopausal symptoms to investigate the negative impact of menopause on women’s life. Furthermore, an article that systematically reviewed qualitative evidence on women’s experience of menopause found that women experience menopause in different ways depending on their personal, familial, and sociocultural background, and the experience could be either positive or negative [ 60 ]. Therefore, QoL, defined as “an individual’s perception of their position in life, in the context of the culture and value system in which they live, and in relation to their goals, expectations, standards, and concerns” [ 61 ], could be used to indicate the extent to which menopause affects a woman’s life.…”

Section: Discussionmentioning

confidence: 99%

Exercise and Quality of Life in Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nguyen

Thanh

Tran

et al. 2020

IJERPH

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Menopausal symptoms are associated with deterioration in physical, mental, and sexual health, lowering women’s quality of life (QoL). Our study objective is to examine the effect of exercise on QoL in women with menopausal symptoms. After initially identifying 1306 studies published on PubMed, Web of Science, Scopus, and Cochrane Library before June 2020, two researchers independently selected nine randomized controlled trials (RCTs) in which any type of exercise was compared with no active treatment. We assessed the risk of bias in the included studies using the Cochrane risk-of-bias 2.0 tool for RCTs and computed the converged standardized mean difference with a 95% confidence interval. We found evidences for the positive effects of exercise on physical and psychological QoL scores in women with menopausal symptoms. However, there was no evidence for the effects of exercise on general, social, and menopause-specific QoL scores. The most common interventions for women with menopausal and urinary symptoms were yoga and pelvic floor muscle training (PFMT), respectively. In our meta-analyses, while yoga significantly improved physical QoL, its effects on general, psychological, sexual, and vasomotor symptoms QoL scores as well as the effect of PFMT on general QoL were not significant. Our findings suggest that well-designed studies are needed to confirm the effect of exercise on QoL in women with menopausal symptoms.

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Section: Discussionmentioning

confidence: 99%

Exercise and Quality of Life in Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nguyen

Thanh

Tran

et al. 2020

IJERPH

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“…Menopause is defined as the permanent termination of menstruation due to exhaustion of the resting primordial follicle pool and loss of ovarian follicular activity, and usually occurs at 51 years of age averagely (ranging from 40 to 60 years) [ 1 ]. Despite it’s a natural process, menopause significantly affects women, both physically and emotionally, which is closely associated with psychosocial issues of midlife [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Differential analysis of quantitative proteome and acetyl-proteome profiling between premenopausal and postmenopausal ovarian tissues

Shi

et al. 2018

Clin Proteom

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BackgroundNatural menopause is always accompanied by specific signs and symptoms, suggesting physiological changes in this peoriod. However, no systematic study has assessed the changes at molecular level in the ovaries during the menopausal transition so far. This study integrated quantitative proteome and acetyl-proteome to comprehensively uncover the changes of ovarian protein and protein-acetylation profiles in this transitional period. The findings would provide novel insights into the biology of menopause and help relieve and treat the associated signs and symptoms, further improving the women’s health care.MethodsFreshly thawed ovarian tissue samples obtained from premenopausal and postmenopausal women were assessed with Tandem Mass Tags for the quantitative analysis of the global profile and acetyl-proteomes by 2-dimensional separation and LC–MS/MS.ResultsComprehensively, 4210 types of protein, with 3551 types quantifiable were detected. 3047 acetylated sites in 1583 types of protein with 2256 quantifiable in 1248 proteins were detected. By comparing the global and acetylated proteome profiles for postmenopausal women and premenopausal women, 151 types of proteins were found upregulated and 65 were downregulated, along with 23 acetylated sites upregulated and 220 sites downregulated. For Immune response, the complement and coagulation cascades plus the citrate cycle and cellular detoxification were found to be significantly enhanced, while the extracellular structure and matrix organization, ECM-receptor interactions plus the infections were markedly suppressed. In addition, the amino acids around the acetylated sites were enriched by motif analysis, which can help us uncover amino acid sequence and search for the specific target in the subsequent study.ConclusionGlobal and acetylated proteome Profiles in ovary differ between the premenopausal and postmenopausal groups. These proteomic-level changes may offer some potential biological markers to identify the pathological changes in ovary and help relieve and treat the associated signs and symptoms, and ultimately improve women’s health care.Electronic supplementary materialThe online version of this article (10.1186/s12014-018-9214-0) contains supplementary material, which is available to authorized users.

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“…This study focused on menopausal vasomotor symptoms in the first instance. We recognise that personal, ethnic, cultural, and geographical factors influence the nature and experience of menopause, and that not all women experience vasomotor symptoms at menopause . We comprehensively searched three major databases and it is unlikely we have missed an RCT published elsewhere.…”

Section: Discussionmentioning

confidence: 99%

Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review

Iliodromiti

Wang

Lumsden

et al. 2019

BJOG

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Background There is substantial variation in how menopausal vasomotor symptoms are reported and measured among intervention studies. This has prevented meaningful comparisons between treatments and limited data synthesis. Objectives To review systematically the outcome reporting and measures used to assess menopausal vasomotor symptoms from randomised controlled trials of treatments. Search strategy We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials from inception to May 2018. Selection criteria Randomised controlled trials with a primary outcome of menopausal vasomotor symptoms in women and a sample size of at least 20 women per study arm. Data collection and analysis Data about study characteristics, primary vasomotor‐related outcomes and methods of measuring them. Main results The search identified 5591 studies, 214 of which were included. Forty‐nine different primary reported outcomes were identified for vasomotor symptoms and 16 different tools had been used to measure these outcomes. The most commonly reported outcomes were frequency (97/214), severity (116/214), and intensity (28/114) of vasomotor symptoms or a composite of these outcomes (68/214). There was little consistency in how the frequency and severity/intensity of vasomotor symptoms were defined. Conclusions There is substantial variation in how menopausal vasomotor symptoms have been reported and measured in treatment trials. Future studies should include standardised outcome measures which reflect the priorities of patients, clinicians, and researchers. This is most effectively achieved through the development of a Core Outcome Set. This systematic review is the first step towards development of a Core Outcome Set for menopausal vasomotor symptoms. Tweetable summary Menopausal hot flushes and night sweats have been reported in 49 different ways in clinical research. A core outcome set is urgently required.

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Womenʼs experience of menopause: a systematic review of qualitative evidence

Cited by 87 publications

References 64 publications

Exercise and Quality of Life in Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Exercise and Quality of Life in Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Differential analysis of quantitative proteome and acetyl-proteome profiling between premenopausal and postmenopausal ovarian tissues

Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review

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