Women with overweight, mixed hyperlipidemia, intolerance to glucose and diastolic hypertension

Abstract

Primarily healthy women who attended a practice of General Medicine were examined and coded data were evaluated using two statistical methods (n = 248, aged 36 ± 14 years). It was found that participants with LDL-related (mixed) hyperlipidemia showed higher blood pressure, a higher proportion of alcohol problems and/or smoking compared to normolipidemic women (p ≤ 0.05). These hyperlipidemic women who reported alcohol problems and/or smoking more often showed proteinuria and/or hematuria, rise of LDL/HDL, critical fasting blood glucose and lower HDL-cholesterol compared to hyperlipidemic women reporting healthy lifestyle (p ≤ 0.05). Likewise, high triglycerides were associated with rise of blood pressure and intolerance to glucose (p ≤ 0.05) and also with elevated total cholesterol. Alcohol-related hypertriglyceridemia overlapped with diastolic hypertension, rise of body weight and urine pathology, lowering of HDL-cholesterol and critical fasting blood glucose. The motivating message was that women with mixed hyperlipidemia and healthy lifestyle had functionally renal endothelium and healthy HDL-related baseline measures. Altogether, LDLrelated hyperlipidemia and/or high triglycerides were correlated with diastolic hypertension whereby critical alcohol consumption declined renal endothelium and lowered HDL-cholesterol implicating baseline strategies to neutralize early risk factors.

LDL-Related Intolerance to Glucose, Diastolic Hypertension and Additive Effects of Smoking Were Found with Three Female Study Groups

“…High triglycerides and high cholesterol were related (p = 0.06, Trig ≥ 170 mg/dl, 15% of A, aged 41 ± 16 years, chol ≥ 200 mg/dl, 17% of A, aged 40±19 year). Mixed hyperlipidemia and higher blood pressure were correlated before (p < 0.05, LDL + Trig: 10% of A, aged 35 ± 15 years versus normolipidemia 18% of A, aged 31 ± 11 years) [1]. Current participants were characterized with LDL-C, with high triglycerides (B: Trig ≥ 160 mg/dl: 9% of 65, aged 51 ± 11 years) or with normolipidemia (n = 54 out of B, 83% of 65, aged 33 ± 10 years).…”

“…Three female study groups were enrolled based on equivalent criterions using medical standard procedures as shown before [1]- [3]. The local ethical authority has approved the study program with self control documents and informed written consent of participants (BLÄK-EK No.…”

“…Several local study groups have provided evidence before that men and/or women with LDL-related hypertriglyceridemia have significantly higher blood pressure compared to normolipidemic persons [1]- [3]. Critical alcohol consumption of hyperlipidemic persons aggravates the risk for diastolic hypertension, significant rise of LDL/HDL, lowering of HDL-cholesterol (HDL-C) and rise of urine pathology compared to hyperlipidemic women reporting healthy lifestyle [1].…”

“…Obesity, hypertriglyceridemia and critical alcohol consumption were related with significantly lower serum albumin to triglycerides ratio (Alb/Trig) compared to appropriate controls [1]- [4]. Proteinuria or hematuria were not directly related with smoking or with rise of blood pressure perhaps because evaluated women were relatively young and the majority showed normal biomarkers [1].…”

“…Critical alcohol consumption of hyperlipidemic persons aggravates the risk for diastolic hypertension, significant rise of LDL/HDL, lowering of HDL-cholesterol (HDL-C) and rise of urine pathology compared to hyperlipidemic women reporting healthy lifestyle [1]. Obesity, hypertriglyceridemia and critical alcohol consumption were related with significantly lower serum albumin to triglycerides ratio (Alb/Trig) compared to appropriate controls [1]- [4].…”