Women with preterm premature rupture of the membranes do not benefit from weekly progesterone

17-hydroxyprogesterone caproate for preterm rupture of the membranes: a multicenter, randomized, double-blind, placebo-controlled trial

“…In agreement with the results of a previous study 15 , the present study provides no evidence that 17OHPc is beneficial in women with PROM. Though the trial turned out to be underpowered for the primary outcome, it had reasonable statistical power for the prespecified secondary outcomes, allowing us to conclude that 17OHPc does not prolong pregnancy or reduce perinatal morbidity after PROM.…”

“…Our results are in agreement with a previous, smaller, randomized trial of 17OHPc in women with PROM 15 .…”

“…In some high risk women with intact membranes, such as those with a short cervix 12 or those with a prior history of spontaneous preterm birth 13 , vaginal progesterone or 17-hydroxyprogesterone caproate (17OHPc) appear to reduce the rate of preterm birth and they are recommended in these settings 14 . However, a previous trial found no benefit of 17OHPc for women with PROM, though the trial had limited statistical power because of small sample size 15 .…”

Progestogens for Preterm Birth Prevention

“…Three trials of unique indications were conducted with participants who had indications not addressed by other studies including active-duty military personnel, 39 preterm premature rupture of membranes, 41 and midtrimester amniocentesis. 40 None demonstrated effectiveness for improving the extracted outcomes.…”

Progesteron zur Prävention der Frühgeburt

“…Derzeit gibt es keine Evidenz dafür, dass die Gabe von Progesteron präventiv wirksam ist bei vorzeitigem Blasensprung [42], nach Cerclage [43] oder bei positivem Fibronektintest. In keiner Studie wurde Progesteron zur Akuttokolyse eingesetzt.…”