<i>Meripilus giganteus</i>, commonly known as the giant polypore, is a significant basidiomycete fungus with notable ecological role and potential medicinal applications. Studies on this fungus have revealed its multifaceted bioactive properties, including antioxidant, antimicrobial, anticancer, immunosuppressive, and neuroprotective effects. Through the production of ligninolytic enzymes such as laccase, <i>M. giganteus</i> holds promise for bioremediation and biofuel production. Given these promising findings, further research is warranted, including genome sequencing, proteomic, and metabolomic approaches, to fully elucidate its bioactive pathways and maximize its biotechnological potential.