2022
DOI: 10.3389/fbioe.2022.933505
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Wood-Derived Vascular Patches Loaded With Rapamycin Inhibit Neointimal Hyperplasia

Abstract: Background: Patches are commonly used to close blood vessels after vascular surgery. Most currently used materials are either prosthetics or animal-derived; although natural materials, such as a leaf, can be used as a patch, healing of these natural materials is not optimal; rhodamine and rapamycin have been used to show that coating patches with drugs allow drug delivery to inhibit neointimal hyperplasia that may improve patch healing. Wood is abundant, and its stiffness can be reduced with processing; howeve… Show more

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