Wood Products, Corncob, and Cellulose as Tablet Disintegrating Agents

Direct visualization of Superdisintegrant Hydration Using Environmental Scanning Electron Microscopy

“…[1][2][3] Both the extent and rate of disintegrant swelling upon immersion in water have been related to tablet disintegration, 4 but neither of these factors appears to be uniquely responsible for the disintegration process. [1][2][3] Both the extent and rate of disintegrant swelling upon immersion in water have been related to tablet disintegration, 4 but neither of these factors appears to be uniquely responsible for the disintegration process.…”

Some aspects of formulation and optimization of tablet disintegrants in direct compression systems

“…It has been generally recognized that disintegration time will usually decrease as the disintegrant concentration increases (14-31, 76-78). However, in at least one study, it has been noticed that disintegration time can actually increase with increasing disintegrant concentration (79). Although an unusual case, it has been generally accepted that very high concentrations of tablet disintegrant can cause untoward effects in processing of the tablet (80-82).…”