Wool keratin/zeolitic imidazolate framework-8 composite shape memory sponge with synergistic hemostatic performance for rapid hemorrhage control

Sang, Feng; Yang, Xiao; Hao, Jiahui; Wang, Yuzhen; Si, Xiaoqin; Li, Xujian; Pan, Luqi; Ma, Zhaipu; Shi, Changcan

doi:10.1039/d3tb01660a

Cited by 5 publications

(2 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A characteristic peak at 660 cm –1 was observed in the keratin powder, which was due to the stretching vibration of C–S . Besides, the presence of amide I (1600–1700 cm –1 ), II (1480–1580 cm –1 ), and III (1220–1330 cm –1 ) peaks could be observed in both keratin powders, which is an important indicator for determining the secondary structure of proteins . To further verify the composition of the extracted keratin, we conducted amino acid composition analysis experiments.…”

Section: Results and Discussionmentioning

confidence: 99%

“…29 Besides, the presence of amide I (1600−1700 cm −1 ), II (1480−1580 cm −1 ), and III (1220−1330 cm −1 ) 30 peaks could be observed in both keratin powders, which is an important indicator for determining the secondary structure of proteins. 31 To further verify the composition of the extracted keratin, we conducted amino acid composition analysis experiments. The results showed that keratin contains 17 types of amino acids, with cysteine content accounting for 7.36%, indicating that keratin contains a higher amount of thiol groups for cross-linking reactions (Table S1).…”

Section: Extraction Of Keratin and Preparation Ofmentioning

confidence: 99%

See 1 more Smart Citation

Additive-free Absorbable Keratin Sponge With Procoagulant Activity for Noncompressible Hemostasis

Wang,

Yang,

Yang

et al. 2024

Biomacromolecules

Self Cite

View full text Add to dashboard Cite

The development of a natural, additive-free, absorbable sponge with procoagulant activity for noncompressible hemostasis remains a challenging task. In this study, we extracted high molecular weight keratin (HK) from human hair and transformed it into a hemostatic sponge with a well-interconnected pore structure using a foaming technique, freeze-drying, and oxidation cross-linking. By controlling the cross-linking degree, the resulting sponge demonstrated excellent liquid absorption ability, shape recovery characteristics, and robust mechanical properties. The HK10 sponge exhibited rapid liquid absorption, expanding up to 600% within 5 s. Moreover, the HK sponge showed superior platelet activation and blood cell adhesion capabilities. In SD rat liver defect models, the sponges demonstrated excellent hemostatic performance by sealing the wound and expediting coagulation, reducing the hemostatic time from 825 to 297 s. Furthermore, HK sponges have excellent biosafety, positioning them as a promising absorbable sponge with the potential for the treatment of noncompressible hemostasis.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Section: Extraction Of Keratin and Preparation Ofmentioning

confidence: 99%