Work and Breast Cancer: Recommendations to Address Research Needs

Engel, Connie L.; Rasanayagam, M. Sharima; Gray, Janet; Rizzo, Jeanne

doi:10.1177/1048291118758713

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…The relationship between occupation and breast cancer can be ascertained by collecting data on age at diagnosis of breast cancer, characteristics of breast cancer, demographic characteristics, status of menopause, risk factors, history of occupations, work environment, and exposures. It would help to involve workers in the research on their own occupational risks and exposures (Engel et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Wong

Chan

et al. 2020

Appl Microbiol Biotechnol

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This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus bisporus, Brazilian mushroom Agaricus blazei, Amauroderma rugosum, stout camphor fungus Antrodia camphorata, Jew's ear (black) fungus or black wood ear fungus Auricularia auricula-judae, reishi mushroom or Lingzhi Ganoderma lucidum, Ganoderma sinense, maitake mushroom or sheep's head mushroom Grifola frondosa, lion's mane mushroom or monkey head mushroom Hericium erinaceum, brown beech mushroom Hypsizigus marmoreus, sulfur polypore mushroom Laetiporus sulphureus, Lentinula edodes (shiitake mushroom), Phellinus linteus (Japanese "meshimakobu," Chinese "song gen," Korean "sanghwang," American "black hoof mushroom"), abalone mushroom Pleurotus abalonus, king oyster mushroom Pleurotus eryngii, oyster mushroom Pleurotus ostreatus, tuckahoe or Fu Ling Poria cocos, and split gill mushroom Schizophyllum commune. Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. Agaricus placomycesThe 68-kDa laccase from Agaricus placomyces belongs to a family of copper-containing oxidases involved in lignin degradation and possessing anticancer activity (Mizerska-Dudka et al. 2015). It potently expressed antiproliferative activity toward MCF-7 human breast cancer cells with an IC50 of 1.8 μM (Sun et al. 2012). Agaricus sylvaticusIn a randomized, double-blind, and placebo-controlled clinical trial, 46 patients with stage II and III breast cancer who received chemotherapy demonstrated an improved appetite and fewer gastrointestinal complaints, nausea, and vomiting following dietary supplementation with A. sylvaticus (2.1 g/day) (Valadares et al. 2013). Amauroderma rude Amauroderma rude had higher tumoricidal activity than Ganoderma lucidum. A. rude lowered cell survival and triggered apoptosis in MDA-MB-231 breast cancer cells. Tumor growth in athymic nude mice bearing MDA-MB-231-xenografts was retarded and tumor cell death was promoted by treatment with A. rude. Expression of the c-Myc oncogene was downregulated . A. rude exhibited a higher content of ergosterol (ergosta-5,7,22-trien-3β-ol) in comparison with 12 other mushrooms examined. Under the influence of ergosterol, the viability of MDA-MB-231 breast cancer cells was reduced, whereas expression of the tumor suppressor Foxo3 and downstream signaling molecules including BimL, BimS, Fas, and FasL was enhanced resulting in apoptosis of the breast cancer cells (Li et al. 2015).Amauroderma rugosum (also known as black Lingzhi, a member of five-color Lingzhi) Organic molecules from A. rugosum inhibited oxidant activity, tumor necrosis factor-α and nitric oxide formation, and MCF7 cell proliferation (Zhang et al. 2017a). A single treatment with pulverized A. rugosum (2000 mg/kg) by mouth did not impair growth, blood parameters, histological structures of t...

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Section: Discussionmentioning

confidence: 99%

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Wong

Chan

et al. 2020

Appl Microbiol Biotechnol

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“… 2 PPIE in research can lay the groundwork for improving health care and services for disadvantaged groups; see Wallerstein, 2006 ; Engel et al, 2018 . It can also have personal benefits for public contributors, developing life and employment skills and empowering individuals and communities ( Popay and Porroche-Escudero, 2018 ).…”

Section: Footnotesmentioning

confidence: 99%

Democratic Justifications for Patient Public Involvement and Engagement in Health Research: An Exploration of the Theoretical Debates and Practical Challenges

Frith

2023

The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine

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The literature on patient public involvement and engagement (PPIE) in health research has grown significantly in the last decade, with a diverse range of definitions and topologies promulgated. This has led to disputes over what the central functions and purpose of PPIE in health research is, and this in turn makes it difficult to assess and evaluate PPIE in practice. This paper argues that the most important function of PPIE is the attempt to make health research more democratic. Bringing this function to the fore and locating PPIE in the wider context of changes in contemporary forms of democratic engagement provides greater conceptual clarity over what PPIE in research should be trying to achieve. Conceptualizing PPIE as a form of democratization has a number of benefits. First, theories of what are appropriate, normatively justifiable and workable criteria for PPIE practices can be developed, and this can provide tools to address the legitimacy and accountability questions that have troubled the PPIE community. Second, this work can be used to form the basis of a research agenda to investigate how PPIE in health research operates, and how it can facilitate and/or improve democratic processes in health research.

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Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland

Matouskova

Szabo

Daum

et al. 2022

Reproductive Toxicology

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Work and Breast Cancer: Recommendations to Address Research Needs

Cited by 3 publications

References 43 publications

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Democratic Justifications for Patient Public Involvement and Engagement in Health Research: An Exploration of the Theoretical Debates and Practical Challenges

Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland

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