Work at night and breast cancer – report on evidence-based options for preventive actions

Bonde, Jens Peter; Hansen, Johnni; Kolstad, Henrik Albert; Mikkelsen, Sigurd; Ølsen, Jørgen H.; Blask, David E.; Härmä, Mikko; Kjuus, Helge; Koning, Harry J. de; Olsen, Jørn; Møller, Mette; Schernhammer, Eva; Stevens, Richard G.; Åkerstedt, Torbjörn

doi:10.5271/sjweh.3282

Cited by 87 publications

(72 citation statements)

References 57 publications

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“…It would also be possible to use only red light at night, because red light does not interfere with melatonin production. If the major problem is the challenge of the circadian rhythm or interaction between night work and genetic predisposition, other preventive measures should be evaluated (46). In conclusion, we found an increased risk of breast cancer among shift workers who have had night work in their schedule.…”

Section: Shift Work and Cancermentioning

confidence: 68%

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Breast cancer among shift workers: results of the WOLF longitudinal cohort study

Knutsson¹,

Alfredsson²,

Karlsson³

et al. 2012

Scand J Work Environ Health

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102

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This cohort study showed that shift work with night shifts is associated with increased risk of breast cancer, but not shift work without night shifts. Research on the disease mechanisms needs to be intensified. Original article Scand J Work Environ Health. 2013;39(2):170-177. doi:10.5271/sjweh.3323 Breast cancer among shift workers: results of the WOLF longitudinal cohort study Objective The aim of this study was to investigate whether shift work (with or without night work) is associated with increased risk of breast cancer. Affiliation MethodsThe population consisted of 4036 women. Data were obtained from WOLF (Work, Lipids, and Fibrinogen), a longitudinal cohort study. Information about baseline characteristics was based on questionnaire responses and medical examination. Cancer incidence from baseline to follow-up was obtained from the national cancer registry. Two exposure groups were identified: shift work with and without night work. The group with day work only was used as the reference group in the analysis. Cox regression analysis was used to calculate relative risk. ResultsIn total, 94 women developed breast cancer during follow-up. The average follow-up time was 12.4 years. The hazard ratio for breast cancer was 1.23 [95% confidence interval (95% CI) 0.70-2.17] for shifts without night work and 2.02 (95% CI 1.03-3.95) for shifts with night work. When including only women <60 years of age, the risk estimates were 1.18 (95% CI 0.67-2.07) for shifts without night work, and 2.15 (95% CI 1.10-4.21) for shifts with night work. ConclusionsOur results indicate an increased risk for breast cancer among women who work shifts that includes night work.

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Section: Shift Work and Cancermentioning

confidence: 68%

“…If the melatonin suppression is the crucial factor, one preventive method could be to reduce exposure to LAN (46). It would also be possible to use only red light at night, because red light does not interfere with melatonin production.…”

Section: Shift Work and Cancermentioning

confidence: 99%

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

Knutsson¹,

Alfredsson²,

Karlsson³

et al. 2012

Scand J Work Environ Health

Self Cite

102

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“…The International Agency for Research on Cancer (IARC) has classified shift work, involving circadian disruption, as probably carcinogenic to humans. This designation was mainly based on the experimental and epidemiologic evidence for circadian disruption and breast cancer and prompted a panel of experts to suggest preventive measures [9].…”

Section: Introductionmentioning

confidence: 99%

The effect of melatonin on sleep and quality of life in patients with advanced breast cancer

Innominato

Lim

Palesh

et al. 2015

Support Care Cancer

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“…It is noteworthy that both elevated BP and inflammation have been associated with a number of other late-onset disorders, such as dementia and cancer. Although the body of literature on the relationship between shift work and these conditions is still emerging (13,14), understanding the effect of misalignment may have a far-reaching impact beyond the field of cardiovascular biology.…”

Section: Inflammationmentioning

confidence: 99%

Beating against the clock

Zhang

Jain

2016

Proc. Natl. Acad. Sci. U.S.A.

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Work at night and breast cancer – report on evidence-based options for preventive actions

Cited by 87 publications

References 57 publications

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

The effect of melatonin on sleep and quality of life in patients with advanced breast cancer

Beating against the clock

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