OBJECTIVE -To estimate the prevalence of physical limitations associated with diabetes among U.S. adults Ն18 years of age.RESEARCH DESIGN AND METHODS -We conducted a cross-sectional analysis of the association between diabetes status and physical limitations using the 1997-1999 National Health Interview Survey (NHIS). Physical limitation was defined from self-reported degree of difficulty with nine tasks.RESULTS -People with diabetes had a higher proportion of any physical limitation than did people without diabetes overall (66 vs. 29%, P Ͻ 0.001), for both men (59 vs. 24%, P Ͻ 0.001) and women (72 vs. 34%, P Ͻ 0.001). Compared with those without diabetes, a higher proportion of people with diabetes had some physical limitation among all age groups, and the difference declined (all P Ͻ 0.001) with increasing age (46 vs. 18% for 18 -44 years, 63 vs. 35% for 45-64 years, 74 vs. 53% for 65-74 years, and 85 vs. 70% for those 75 years and older). After controlling for demographic characteristics and several other confounders, the odds ratio of physical limitation among adults with diabetes versus those without diabetes was 1.9 (95% CI: 1.8 -2.1).CONCLUSIONS -People with diabetes are much more likely to have a physical limitation than those without diabetes. Interventions are needed in this population to reduce progression from impairment to physical limitation and from physical limitation to disability, especially because the prevalence of diabetes is projected to increase dramatically in the next several decades.