Context: In recent decades, women’s participation in the labor market has increased dramatically. However, this has confronted working women with work-family conflicts. Objective: This systematic review aimed to find the factors related to work-family conflicts befallen women working. Methods: All scientific articles published on the subject from June 2000 until June 2021 were searched in five databases (Science Direct, Web of Science, PubMed, Embase, Scopus, and Google Scholar) using the Keywords of factor, female, working, work-life balance, life-work imbalance. Results: We found 3967 articles in the databases mentioned. After removing duplicate items, the titles and abstracts of 2573 articles were screened, 34 full-texts of which were reviewed, leading to the final selection of 31 articles (13 qualitative studies and 17 quantitative studies). Then we searched for the documents that cited any of the initially included studies, as well as the references of the primarily included studies; however, no additional articles were found in this step. We categorized the factors related to work-life conflicts into four categories and 22 sub-categories. The first category was individual factors (e.g., individual capacities and skills); the second category was interpersonal factors (e.g., spousal support and lack of family support); the third category was organizational factors (e.g., organizational policies and working hours), and the fourth category was cultural factors (e.g., patriarchal hegemony in society and family-friendly culture). Conclusions: First, individual skills are needed to be paid more attention to, such as planning, which may be simply modifiable and has the potential to inform therapeutic interventions and preventative strategies. Second, foremen and directors should be informed about the importance of work-life conflicts experienced by women and their decisive role in creating a work-life balance to help improve their working conditions.