Work in progress: clinical evaluation of Tc-99m-trimethylbromo-IDA and Tc-99m-diisopropyl-IDA for hepatobiliary imaging.

Klingensmith, William C.; Fritzberg, Alan R.; Spitzer, Victor M.; Kuni, Christopher C.; Williamson, Michael; Gerhold, J P

doi:10.1148/radiology.146.1.6681569

Cited by 25 publications

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“…5) and great resistance to displacement by bilirubin (Tables 1 and 2). These characteristics are important when studying patients with deep jaundice (29). Both of these agents are now approved by the United States Food and Drug Administration for routine use.…”

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confidence: 99%

Technetium-99m-iminodiacetic acid organic anions: Review of biokinetics and clinical application in hepatology

Krishnamurthy

1989

Hepatology

104

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Technetium-99m-labeled iminodiacetic acid analogs are a new class of organic anions, taken up and secreted by hepatocyte into hepatic bile by a carrier-mediated organic anion pathway. They provide a new dimension in the assessment of pathophysiology and morphology of the hepatobiliary system. The amount of uptake and the rapidity of its elimination from the liver is dependent upon the structural configuration of the agent as well as the functional integrity of the hepatocyte and the patency of the biliary system. The clinical areas for application are wide and include most of the hepatobiliary diseases. Technetium-99m-iminodiacetic acid, an agent well suited for both planar and single photon tomographic scintigraphy, is ideal for early diagnosis prior to anatomical changes in the hepatobiliary system. The data collection directly from the liver provides quantitation of both regional and global liver diseases. The count-based method for measuring gallbladder emptying overcomes the theoretical disadvantages of geometric tests. Biokinetics and current clinical application of six of the 99mTc-iminodiacetic acid agents are reviewed, and the potential future clinical and research areas of application are indicated.

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confidence: 99%

Technetium-99m-iminodiacetic acid organic anions: Review of biokinetics and clinical application in hepatology

Krishnamurthy

1989

Hepatology

104

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“…9 Kuni and associates 13 suggest that knowledge of the histopathological correlates of scintigraphic abnormalities could prove useful in differentiating rejection from other parenchymal pathologies in transplant recipients; however, other researchers found that scintigraphic differentiation between rejection and other parenchymal complications is difficult. 1,8,9,14,15 The present study evaluated the role of quantitative hepatobiliary scintigraphy in the diagnosis of parenchymal complications in postliver transplant recipients. Hepatocyte extraction fraction value and HPRI were used for quantitative analysis.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2014

Exp Clin Transplant

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Objectives: The aim of this study was to evaluate the usefulness of the hepatic parenchymal retention index in the early diagnosis of parenchymal complications in liver transplant recipients as determined by hepatobiliary scintigraphy. Materials and Methods: This retrospective study reviewed 100 liver transplant recipients who had undergone orthotopic liver transplant. In all cases, hepatobiliary scintigraphy images recorded 7 to 10 days posttransplant were quantitatively reinterpreted according to hepatic parenchymal retention index. The hepatocyte extraction fraction value was also calculated. Scintigraphic findings as well as clinical, laboratory, and biopsy results were assessed. Results: Quantitative analysis showed normal hepatocyte extraction fraction value in all subjects. However, significant differences in hepatic parenchymal retention index were observed. Thus, subjects were divided into 3 groups: group 1 (n=75), normal; group 2 (n=15), severely elevated; group 3 (n=10), mildly-to-moderately elevated hepatic parenchymal retention index. Evaluation of histopathological, clinical, and laboratory findings showed normal grafts in all group 1 recipients, acute rejection in all group 2 recipients, and hepatocyte damage/intrahepatic cholestasis in all group 3 recipients. Conclusions: Based on these findings, we determined that hepatocyte extraction fraction value was not useful, whereas hepatic parenchymal retention index was beneficial for early and accurate diagnosis of parenchymal complications in liver transplant recipients.

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“…It is characterized by very low urinary excretion, avid uptake by hepatocytes even at very high levels of bilirubin in the plasma, and rapid hepatic transit into the biliary tract. Clinical studies have confirmed its great usefulness (9). A similar compound, 3-iodo-2,6-diethylphenylcarbamoylmethyliminodiacer tic acid, JODIDA, manufactured by SOLCO company, is said to behave similarly, i. e. to show more efficient extraction from the blood than conventional IDA derivatives, to have a very low urinary excretion and to provide good scintigrams of the liver and biliary tract even at bilirubin levels close to 30 mg per 100 ml (20).…”

Section: Methodsmentioning

confidence: 99%

“…m Tc-EHIDA shows similar kinetics of uptake and elimination, but the extraction coefficient for this substance seems to be higher than for " m Tc-HIDA (19); the same applies to " m Tc-PIPIDA, but the latter is secreted at a slower rate into the bile (6,19). " m Tc-DISIDA is as efficiently extracted by hepatocytes as is the EHIDA complex of " m T c but its excretion into the bile is faster (9,18). Also, " m Tc-BIDA is characterized by a high extraction coefficient and low elimination via the urinary tract (less than 2%); at the same time, the hepatic transit time of the substance is much longer than that of the other IDA derivatives (16,19).…”

Section: Introductionmentioning

confidence: 99%

Comparison in Rabbits of Chole-Scintigraphic Properties of Several 99mTc-IDA Derivatives

Kapuściński¹,

Liniecki²,

Durski³

et al. 1986

Nuklearmedizin

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Pathways and kinetics of excretion were compared to four 99mTc-IDA derivatives in healthy rabbits of both sexes. Assessment of differences between the compounds was based upon: plasma clearance, characteristics of time-activity curves measured scintigraphically over the liver (time of the peak Tmax; time for decline of activity to half the peak value - T50%), and hepatocytic mean transit time (MTT) as derived after deconvolution of the hepatic time-activity curve. Hepatocyte transit time was short and similar to 99mTc-complexes of Mebrofenin, 2,4-diethyl IDA (HEPIDA) and 3-iodo-2,6- diethylphenylcarbamoylmethyliminodiacetic acid (JODIDA); it was evidently longer for 99mTc-p-butyl-IDA (BIDA). 99mTc-HEPIDA displayed significant urinary elimination; the remaining three compounds were excreted practically completely via the biliary route. It is concluded that optimal parameters were displayed by 99mTc-Mebrofenin and 99mTc-JODIDA.

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Work in progress: clinical evaluation of Tc-99m-trimethylbromo-IDA and Tc-99m-diisopropyl-IDA for hepatobiliary imaging.

Cited by 25 publications

References 0 publications

Technetium-99m-iminodiacetic acid organic anions: Review of biokinetics and clinical application in hepatology

Technetium-99m-iminodiacetic acid organic anions: Review of biokinetics and clinical application in hepatology

Untitled

Comparison in Rabbits of Chole-Scintigraphic Properties of Several 99mTc-IDA Derivatives

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