Work in the metal industry and nasopharyngeal cancer mortality among formaldehyde-exposed workers

Marsh, Gary M.; Youk, Ada O.; Buchanich, Jeanine M.; Erdal, Serap; Esmen, Nurtan A.

doi:10.1016/j.yrtph.2007.04.006

Cited by 74 publications

(66 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The approaches we describe led to the quantifiable assessment of time-varying, ARV drug-specific exposureresponse relationships. These exposure-response relationships employed duration of exposure, cumulative exposure, and average intensity of exposure, as is often done in occupational epidemiological research [10][11][12][13][14]. Additionally, pharmacoepidemiological studies can also readily incorporate exposure lags and latency into complex exposure-response assessments and well-designed comparative effectiveness research.…”

Section: Discussionmentioning

confidence: 99%

“…Generalizing these methods for use with other pharmacy claims data-based studies of health outcomes and benefitrisk assessments is straightforward. The major objectives of the occupational studies that have employed such methods were to identify the health consequences of workplace exposure, provide data for setting standards for protection of doi: 10.7243/2054-9911-3-2 workers to potentially toxic substances, make projections of risk to less-exposed populations, and elucidate exposureresponse relationships [11][12][13][14][20][21][22][23]. The exposures may be either continuous or intermittent and there may be several competing exposures and covariables that change over time.…”

Section: Discussionmentioning

confidence: 99%

“…org/university-of-pittsburgh/ocmap-software). This structured approach permitted the extrapolation of exposures and risks, as defined in occupational epidemiology, to our assessment of drug exposures and event risk in pharmacoepidemiology [10][11][12][13][14]. The detailed prescription histories for longitudinal drug exposures are often as complex as occupational exposure histories [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…This structured approach permitted the extrapolation of exposures and risks, as defined in occupational epidemiology, to our assessment of drug exposures and event risk in pharmacoepidemiology [10][11][12][13][14]. The detailed prescription histories for longitudinal drug exposures are often as complex as occupational exposure histories [10][11][12][13][14]. We computed typical occupational exposure metrics (duration of exposure, cumulative exposure, and average intensity of exposure) in our nested case-control study, along with the assessment of drug lag periods and latency, defined as time since first drug exposure [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…The detailed prescription histories for longitudinal drug exposures are often as complex as occupational exposure histories [10][11][12][13][14]. We computed typical occupational exposure metrics (duration of exposure, cumulative exposure, and average intensity of exposure) in our nested case-control study, along with the assessment of drug lag periods and latency, defined as time since first drug exposure [10][11][12][13][14]. By reformatting prescription claims data and using these metrics, we explored drug-exposure relationships in HIV treatment and risk of fracture.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Assessment of risk in longitudinal observational studies with time-varying drug exposures for treatment of a chronic disease

Youk¹,

Mundy²,

Laurent³

et al. 2015

Epidemiol Rep

View full text Add to dashboard Cite

Background: Drug exposures can be continuous or intermittent with several competing exposures which can influence the analysis of exposure-response relationships in longitudinal observational data. Purpose: We report the in-depth application of research methods employed in a nested case-control study to assess risk for fracture among persons with human immunodeficiency virus (HIV) infection treated with antiretroviral (ARV) therapy. These pharmacoepidemiological research methods, extrapolated from occupational epidemiology, permitted detailed exposure-response analysis in longitudinal observational data sources. Methods: Multidrug administrative prescription claims data were reformatted to create time-varying, nonoverlapping drug exposure histories that preserved the information in the original prescriptions. We applied research methods from occupational health to estimate drug-class (N=5) and drug-specific (N=29) exposure summary measures associated with fracture events. Results: Using pharmacy claims from the Clinformatics™ DataMart Multiplan (IMPACT) database, a product of OptumInsight Life Sciences, Inc., 1,929,067 prescription histories from 30,405 ARV-treated HIV subjects were restructured retaining gaps and removing overlaps and encompassments in the prescription histories. Most subjects were dispensed at least three different ARV drugs; over 75% had prescription histories with at least one gap in prescriptions and 23.5% had over 65 prescription claims. Drug exposure summary metrics were computed from the restructured claims to determine time-varying exposureresponse relationships for individual ARV drug exposures and fractures. Conclusions: We report a research method to assess drug exposure using administrative prescription claims in observational data that goes beyond dichotomous or cumulative exposures measurements of HIV drug classes and specific ARV drugs. The time-varying measures derived here are easily applicable to other observational data sources such as drug exposures for other chronic diseases where prescription histories are complex and evolve over time.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Assessment of risk in longitudinal observational studies with time-varying drug exposures for treatment of a chronic disease

Youk¹,

Mundy²,

Laurent³

et al. 2015

Epidemiol Rep

View full text Add to dashboard Cite

show abstract

Formaldehyde Exposure and Human Health Risks

Sonawane,

Kancherla

2023

Patty's Toxicology

View full text Add to dashboard Cite

This chapter primarily focuses on the human health effects of formaldehyde inhalation exposure. It summarizes significant published findings and recently peer‐reviewed health risk assessments of national and international organizations on formaldehyde exposure including current regulatory standards. Formaldehyde is a flammable gas at room temperature and is found in consumer products and used in manufacturing processes, such as resins in composite wood products. Environmental exposure to formaldehyde can occur via inhalation, dermal, and ingestion routes. The most common route of formaldehyde exposure is inhalation resulting from breathing formaldehyde‐contaminated air. Formaldehyde enters the environment from natural and anthropogenic combustion sources, industrial on‐site releases, and off‐gassing of products containing formaldehyde. Acute and chronic exposures to formaldehyde through home furnishings, environmental contamination, cosmetics, and indoor and outdoor air pollution poses potential public health risks. Epidemiological, clinical, and experimental animal studies have shown that formaldehyde exposures are associated with potentially adverse human noncancer health outcomes. The epidemiologic evidence has shown an association between formaldehyde exposure and nasopharyngeal cancer as causal in human studies. Positive associations between formaldehyde exposure and lymphohematopoietic cancers have been reported for chemical workers, embalmers, anatomists, and pathologists. The mode(s) or mechanism(s) of formaldehyde exposure and reported cancers are not well understood; however, its exposure has been shown to be associated with the key events related to carcinogenicity.

show abstract

Mortality from solid tumors in the updated NCI formaldehyde cohort

McLaughlin

Tarone

2014

American J Industrial Med

View full text Add to dashboard Cite

Work in the metal industry and nasopharyngeal cancer mortality among formaldehyde-exposed workers

Cited by 74 publications

References 41 publications

Assessment of risk in longitudinal observational studies with time-varying drug exposures for treatment of a chronic disease

Assessment of risk in longitudinal observational studies with time-varying drug exposures for treatment of a chronic disease

Formaldehyde Exposure and Human Health Risks

Mortality from solid tumors in the updated NCI formaldehyde cohort

Contact Info

Product

Resources

About