Evidence consistently indicates that common conditions including migraine, 1-8 low back pain, 9,10 diabetes, 1 1 , 1 2 allergic rhinitis, 5 , 1 3 -1 8 gastroesophageal reflux, 19-21 and depression 5,10,22-25 dominate healthrelated lost labor time costs. Among these, depression is among the most costly because it is highly prevalent and comorbid with other conditions. Furthermore, although workers with depression are usually present at work, their performance can be substantially reduced.Model-based estimates indicate that depression costs US employers $24 billion annually in lost productive work time. 23 However, some notable limitations challenge the relevance of this and other estimates. Using a human capital approach, this model makes important assumptions regarding the prevalence of depression in the workforce, the duration of depressive episodes, their imputed impact on productive time at work, and the cost to employers. Furthermore, although stated in 1990 terms, the cost estimate is based on data collected in the early to mid-1980s. The management and treatment of depression has changed substantially since the 1980s; use of pharmaceutical care and, more generally, access to care have increased 26 and may have influenced disability status and how work time is lost.