Work‐related contact urticaria to <i>Cannabis sativa</i>

Williams, C.; Thompstone, J.; Wilkinson, S. M.

doi:10.1111/j.1600-0536.2007.01169.x

Cited by 57 publications

(36 citation statements)

References 4 publications

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“…Isolated cases of allergic hypersensitivity to Cannabis sativa have been described, including rhinoconjunctivitis due to inhalation of cannabis pollen, 3 urticaria and contact dermatitis due to handling of cannabis plants, 4,5 and anaphylaxis due to cannabis ingestion. 6 Paradoxically, the protective action of cannabis against allergies has also been described.…”

Section: Discussionmentioning

confidence: 99%

Allergic hypersensitivity to cannabis in patients with allergy and illicit drug users

Armentia

Castrodeza²,

Ruiz-Muñoz³

et al. 2011

Allergologia et Immunopathologia

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Background: Cannabis is the illicit drug most widely used by young people in high-income countries. Allergy symptoms have only occasionally been reported as one of the adverse health effects of cannabis use. Objectives: To study IgE-mediated response to cannabis in drug users, atopic patients, and healthy controls. Methods: Asthmatic patients sensitised to pollen, and all patients sensitised to tobacco, tomato and latex, considered as cross-reacting allergens, were selected from a data base of 21,582 patients. Drug users attending a drug-rehabilitation clinic were also included. Controls were 200 non-atopic blood donors. Specific IgE determination, prick tests and specific challenge with cannabis extracts were performed in patients and controls. Results: Overall, 340 patients, mean age 26.9 ± 10.7 years, were included. Males (61.4%) were the most sensitised to cannabis (p < 0.001). All cannabis-sensitised patients were alcohol users. Eighteen (72%) of the patients allergic to tomato were sensitised to cannabis, but a positive specific challenge to cannabis was highest in patients sensitised to tobacco (13/21, 61.9%), (p < 0.001). Pollen allergy was not a risk factor for cannabis sensitisation. Prick tests and IgE for cannabis had a good sensitivity (92 and 88.1%, respectively) and specificity (87.1 and 96%) for cannabis sensitisation. Conclusions: Cannabis may be an important allergen in young people. Patients previously sensitised to tobacco or tomato are at risk. Cannabis prick tests and IgE were useful in detecting sensitisation.

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Section: Discussionmentioning

confidence: 99%

Allergic hypersensitivity to cannabis in patients with allergy and illicit drug users

Armentia

Castrodeza²,

Ruiz-Muñoz³

et al. 2011

Allergologia et Immunopathologia

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“…Although several reports on occupational cutaneous and respiratory allergies to different members of the Cannabaceae family like industrial hemp and hop (Humulus lupulus) have been published (Herzinger et al 2011;Spiewak et al 2001;Williams et al 2008), descriptions of genuine IgE-dependent allergic reactions in drug abusers remain rare. This under-reporting probably results from the illegal status of cannabis use, which makes the patients reluctant to admit their abuse.…”

Section: Prevalencementioning

confidence: 99%

“…Handling of C. sativa plants may lead to contact urticaria (Majmudar et al 2006;Williams et al 2008) and contact dermatitis (Williams et al 2008). Periorbital angioedema may occasionally be triggered by cannabis allergens that became airborne (Tessmer et al 2012).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Cannabis Allergy: What do We Know Anno 2015

Decuyper

Ryckebosch

Gasse

et al. 2015

Arch. Immunol. Ther. Exp.

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For about a decade, IgE-mediated cannabis (marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may lead to a cannabis sensitization and/or allergy. The clinical manifestations of a cannabis allergy can vary from mild to lifethreatening reactions, often depending on the route of exposure. In addition, sensitization to cannabis allergens can trigger various secondary cross-allergies, mostly for plant-derived food. This clinical entity, which we have designated as the ''cannabis-fruit/vegetable syndrome'' might also imply cross-reactivity with tobacco, latex and plant-food derived alcoholic beverages. These secondary cross-allergies are mainly described in Europe and appear to result from cross-reactivity between non-specific lipid transfer proteins or thaumatin-like proteins present in Cannabis sativa and their homologues that are ubiquitously distributed throughout plant kingdom. At present, diagnosis of cannabis-related allergies rests upon a thorough history completed with skin testing using native extracts from buds and leaves. However, quantification of specific IgE antibodies and basophil activation tests can also be helpful to establish correct diagnosis. In the absence of a cure, treatment comprises absolute avoidance measures including a stop of any further cannabis (ab)use.

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“…Urticaria has also occurred in forensic specialists and law enforcement officers following the handling of cannabis [Herzinger et al 2011;Majmudar et al 2006;Mayoral et al 2008;Williams et al 2008]. Several of these plant components have recently been shown to produce high molecular weight proteins that can result in the allergic sensitization following personal exposure [Nayak et al 2013].…”

Section: Hempmentioning

confidence: 99%

Evaluation of a medicinal cannabis manufacturing facility with an indoor and outdoor grow operation.

2018

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Work‐related contact urticaria to Cannabis sativa

Cited by 57 publications

References 4 publications

Allergic hypersensitivity to cannabis in patients with allergy and illicit drug users

Allergic hypersensitivity to cannabis in patients with allergy and illicit drug users

Cannabis Allergy: What do We Know Anno 2015

Evaluation of a medicinal cannabis manufacturing facility with an indoor and outdoor grow operation.

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