Through this research, system engineering will be applied related to the analysis of work systems in hospitals, especially government hospitals where the workload is very high. The object of this research is nurses who work in emergency rooms. The purpose of this study is to apply engineering to the medical world that has been carried out in the manufacturing industry. Similarly, operators who work in the industrial world experience high levels of fatigue such as nurses. This is what underlies this research. Nurses have a high level of fatigue compared to nurses who work in other departments. The high level of fatigue makes it difficult for workers to distillate and focus while working and increases the danger of work fortunes produced by human error and affects the psychological condition of the nurse. Based on the above conditions and impacts, further research needs to be done on a work systems analysis to condense nurses tiredness using the macro ergonomics approach of the System Engineering Initiative for Patient Safety (SEIPS) model in hospitals based on observations and interviews of nurses and hospital management. The expected output is that each nurse does not experience severe fatigue to make maximum patient care.