BackgroundThere is a gap in the literature on identifying and describing effective interventions for the retention of newly graduated registered nurses in hospital settings. To the best of our knowledge, no systematic review has been conducted on this issue.AimTo identify effective interventions that promote the retention of newly graduated registered nurses in the hospital setting and their components.DesignA systematic review was conducted according to PRISMA 2020 Statement.MethodsInformation derived from the PubMed, CINAHL, Scopus, PsycINFO and Cochrane Library databases was reviewed, for the period January 2012–October 2022. Screening, data extraction and quality appraisal were conducted independently by two reviewers. The Joanna Briggs Institute Critical Appraisal tools were used for descriptive, quasi‐experimental and cohort studies. Disagreements between the two reviewers were resolved through discussion.ResultsFollowing the critical appraisal, nine studies were included. The evidence reveals the heterogeneity of programmes developed in the hospital context to promote the retention of newly graduated registered nurses, clarifies the three competencies to be addressed (core, cross‐cutting and specific), their components (programme development framework, duration, content and support components), and shows significant improvements after their implementation.ConclusionsThis systematic review identifies that either nurse residency or individualised mentoring programmes, lasting 1 year, and multi‐component, addressing core and specific competencies and including preceptor or mentor components seem to be the most comprehensive and effective in promoting the retention of new nurses in the hospital setting.Relevance to Clinical PracticeThe knowledge provided by this review will contribute to developing and implementing more effective and context‐specific strategies directed at retaining newly graduated registered nurses and subsequently enhancing patient safety and healthcare costs.No Patient or Public ContributionGiven the study design and focus.