M ultiple trials have shown the benefit of endovascular recanalization therapy in selected stroke patients. [1][2][3] Earlier treatment is associated with better functional outcome. 4 The time from symptom onset to treatment is influenced by prehospital and in-hospital processes. Healthcare systems are being reorganized to offer stroke patients rapid and effective medical care. Stroke services had already changed their workflow since intravenous tPA (tissue-type plasminogen activator) for selected stroke patients was proven effective. 5 Implementation of new strategies to improve the workflow process for treatment with intravenous tPA has led to a significant reduction of in-hospital delay. 6 Providing an optimal diagnostic process and rapid endovascular stroke treatment requires close collaboration of the emergency medical service, emergency department team, stroke team, neurointerventional team, and anesthesia team. Diagnostic imaging and endovascular treatment facilities should be available in little time. Several strategies to reduce the time to endovascular stroke treatment have been proposed. [7][8][9] However, the effect of individual and combined strategies on reducing time to treatment is unclear. We performed a systematic review and meta-analysis on the effectiveness of specific workflow improvement interventions for rapid delivery of endovascular stroke treatment.