Working memory activation of neural networks in the elderly as a function of information processing phase and task complexity

Charroud, Céline; Steffener, Jason; Bars, Emmanuelle Le; Deverdun, Jérémy; Bonafé, Alain; Abdennour, Meriem; Portet, Florence; Molino, François; Stern, Yaakov; Ritchie, Karen; Champfleur, Nicolas Menjot de; Akbaraly, Tasnime

doi:10.1016/j.nlm.2015.10.002

Cited by 13 publications

(9 citation statements)

References 81 publications

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“…In contrast to the overall intact behavioral performance of the ALS patients, we observed some brain regions with enhanced brain activity in ALS patients, compared to controls. Both groups engaged mostly frontoparietal regions, which is in line with previous fMRI studies of working memory 41–43 . Yet, ALS patients exhibited higher activity of frontoparietal and temporal regions in the 2-back condition.…”

Section: Discussionsupporting

confidence: 90%

Brain activity is contingent on neuropsychological function in an fMRI study of Verbal Working Memory in Amyotrophic Lateral Sclerosis

Kobeleva

Machts

Veit

et al. 2021

Preprint

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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that causes progressive degeneration of neurons in motor and non-motor regions, affecting multiple cognitive domains. In order to contribute to the growing research field that employs structural and functional neuroimaging to investigate the effect of ALS on different working memory components, we conducted a functional magnetic resonance imaging (fMRI) study exploring the localization and intensity of alterations in neural activity. Being the first study to specifically address verbal working memory via fMRI in the context of ALS, we employed the verbal n-back task with 0-back and 2-back conditions. Despite ALS patients showing unimpaired accuracies and reaction times, there was significantly increased brain activity of frontotemporal and parietal regions in the 2-back minus 0-back contrast in patients compared to controls. This increased brain activity was largely associated with a better neuropsychological performance within the ALS group, suggesting a compensatory effect. This study therefore adds to the current knowledge on neural correlates of working memory in ALS and contributes to a more nuanced understanding of hyperactivity during cognitive processes in fMRI studies of ALS.

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Section: Discussionsupporting

confidence: 90%

Brain activity is contingent on neuropsychological function in an fMRI study of Verbal Working Memory in Amyotrophic Lateral Sclerosis

Kobeleva

Machts

Veit

et al. 2021

Preprint

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show abstract

“…In accordance with previous literature [11,13,24] In contrast to the overall intact behavioral performance of the ALS patients, some brain regions with enhanced brain activity were observed in ALS patients, compared to controls. Both groups engaged mostly frontoparietal regions, which is in line with previous fMRI studies of working memory [40][41][42]. Yet, ALS patients exhibited higher activity of frontoparietal and temporal regions in the 2-back condition.…”

Section: Discussionsupporting

confidence: 90%

Brain activity is contingent on neuropsychological function in a functional magnetic resonance imaging study of verbal working memory in amyotrophic lateral sclerosis

Kobeleva

Machts

Veit

et al. 2021

Euro J of Neurology

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“…), and dementia was ruled out by neuropsychological tests and an independent committee of neurologists (Charroud et al. ).…”

Section: Methodsmentioning

confidence: 99%

“…History of cardiovascular diseases (stroke, angina pectoris, myocardial infarction, cardiovascular surgery, arrhythmia and heart failure) was established according to standardized questions. Cognitive status was defined with the MMSE (Folstein et al 1975), and dementia was ruled out by neuropsychological tests and an independent committee of neurologists (Charroud et al 2015).…”

Section: Socio-demographic and Clinical Variablesmentioning

confidence: 99%

Retinal vascular fractal dimension and cerebral blood flow, a pilot study

Nadal

Deverdun

Champfleur

et al. 2019

Acta Ophthalmologica

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Purpose: Ocular and brain microcirculation share embryological and histological similarities. The retinal vascular fractal dimension (FD) is a marker of retinal vascular complexity of the vascular tree. The purpose of this study was to explore the relationship between cerebral blood flow (CBF), retinal vascular FD and other retinal vascular markers. Methods: Cross-sectional analysis comprising 26 individuals ≥65 years old from the Cognitive REServe and Clinical ENDOphenotype (CRESCENDO) cohort of relative healthy older adults. Retinal vascular FD was measured from fundus photographs by using the semi-automated Singapore Eye Vessel Assessment (SIVA) software. CBF was estimated using a 2D pulsed ASL MRI sequence. Associations between blood flow and retinal parameters were analysed using linear regression models adjusted for age and sex. Results: Cerebral blood flow was positively associated with venular FD (R 2 = 0.32, p = 0.03). This association was stronger in the anterior versus posterior brain territories (R 2 = 0.35 [p = 0.001] versus R 2 = 0.16 [p = 0.07], respectively). Global CBF was correlated with arteriolar branching angle (R 2 = 0.23, p = 0.01) and tortuosity (R 2 = 0.20, p = 0.02). Global CBF was not correlated with other SIVA parameters. Conclusions: Retinal venular complexity summarized by the FD was associated with cerebral blood flow as well as retinal arteriolar tortuosity and branching angle. Larger prospective clinical studies are needed to confirm these results.

show abstract

Working memory activation of neural networks in the elderly as a function of information processing phase and task complexity

Cited by 13 publications

References 81 publications

Brain activity is contingent on neuropsychological function in an fMRI study of Verbal Working Memory in Amyotrophic Lateral Sclerosis

Brain activity is contingent on neuropsychological function in an fMRI study of Verbal Working Memory in Amyotrophic Lateral Sclerosis

Brain activity is contingent on neuropsychological function in a functional magnetic resonance imaging study of verbal working memory in amyotrophic lateral sclerosis

Retinal vascular fractal dimension and cerebral blood flow, a pilot study

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