Working Memory and Transcranial-Alternating Current Stimulation—State of the Art: Findings, Missing, and Challenges

Abstract

Working memory (WM) is a cognitive process that involves maintaining and manipulating information for a short period of time. WM is central to many cognitive processes and declines rapidly with age. Deficits in WM are seen in older adults and in patients with dementia, schizophrenia, major depression, mild cognitive impairment, Alzheimer’s disease, etc. The frontal, parietal, and occipital cortices are significantly involved in WM processing and all brain oscillations are implicated in tackling WM tasks, particularly theta and gamma bands. The theta/gamma neural code hypothesis assumes that retained memory items are recorded via theta-nested gamma cycles. Neuronal oscillations can be manipulated by sensory, invasive- and non-invasive brain stimulations. Transcranial alternating-current stimulation (tACS) and repetitive transcranial magnetic stimulation (rTMS) are frequency-tuned non-invasive brain stimulation (NIBS) techniques that have been used to entrain endogenous oscillations in a frequency-specific manner. Compared to rTMS, tACS demonstrates superior cost, tolerability, portability, and safety profile, making it an attractive potential tool for improving cognitive performance. Although cognitive research with tACS is still in its infancy compared to rTMS, a number of studies have shown a promising WM enhancement effect, especially in the elderly and patients with cognitive deficits. This review focuses on the various methods and outcomes of tACS on WM in healthy and unhealthy human adults and highlights the established findings, unknowns, challenges, and perspectives important for translating laboratory tACS into realistic clinical settings. This will allow researchers to identify gaps in the literature and develop frequency-tuned tACS protocols with promising safety and efficacy outcomes. Therefore, research efforts in this direction should help to consider frequency-tuned tACS as a non-pharmacological tool of cognitive rehabilitation in physiological aging and patients with cognitive deficits.

Nonmedication Devices in Development for the Treatment of Alzheimer’s Disease

“…Although they show great promise, it is our opinion that more research is needed to determine the maximum length of therapeutic effects for these techniques, the optimal administration methods, and efficacy compared to neuropharmacological agents (including how the effects may be modulated by pharmaceuticals), and the potential of combination treatment methods [ 95 ].…”

Transcranial alternating current stimulation combined with sound stimulation improves the cognitive function of patients with Alzheimer's disease: A case report and literature review

“…Approximately 40 Hz is the stimulation frequency used in this experiment because, in previous studies, it has been found that 40-Hz light flicker or 40-Hz tone flickering is applied to an animal or 40-Hz tACS is applied to a patient with AD can improve cognitive function and decrease amyloid and phosphorylated tau levels (13,31,32). The role of gamma frequency (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) in advanced cognitive processes (including attention, learning, and memory) has been studied (33,34).…”

Adjunctive transcranial alternating current stimulation for patients with major depressive disorder: A systematic review and meta-analysis

“…The search terms were as follows: (transcranial alternating current stimulation OR tACS) AND (depression OR depression OR depressive OR depressed OR melancholia). Furthermore, the reference lists of the identified articles (8)(9)(10)(11) and relevant reviews (15,16) were manually searched to avoid missing eligible studies. The more search details were presented in the Supplementary Text.…”