Working Memory Capacity and the Cognitive Underpinnings of Syntactic Processing

O’Rourke, Polly

doi:10.3765/exabs.v0i0.772

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…In clinical trials, subjects diagnosed with mild AD demonstrated lower amplitudes and ampli ed latencies in ERPs associated with working memory, attention, and executive function (Cecchi et al, 2015;Olichney et al, 2008). These ndings suggest complex relationships between working memory and other cognitive processes in the context of ERP components, particularly the late-positive P6 (Guillem et al, 1995;O'Rourke, 2013). The P6 is shown to function as a binder for stimuli in memory recognition tasks involving previously encountered items (Xia et al, 2020).…”

Section: The Frontoparietal Network (Fpn)mentioning

confidence: 94%

Evaluating Frontoparietal Network Topography for Diagnostic Markers of Alzheimer’s Disease

Rogers

2024

Preprint

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Numerous prospective biomarkers are being studied for their ability to diagnose various stages of Alzheimer’s Disease (AD). High-density electroencephalogram (EEG) methods show promise as an accurate, economical, non-invasive approach to measuring the electrical potentials of brains associated with AD. These event-related potentials (ERPs) may serve as clinically useful biomarkers of AD. Through analysis of secondary data, the present study examined the performance and distribution of N4/P6 ERPs across the frontoparietal network (FPN) using EEG topographic mapping. ERP measures and memory as a function of reaction time (RT) were compared between a group of (N = 63) mild untreated AD patients and a control group of (N = 73) healthy age-matched adults. A concurrent cross-modal associative memory test and 128-channel high-density EEG facilitated data collection. By targeting select frontal and parietal EEG reference channels based on N4/P6 component time windows and positivity; our findings demonstrate statistically significant group variations between controls and patients in N4/P6 peak amplitudes and latencies during cross-modal testing, though there was no interaction effect. Our results also support that the N4 ERP might be stronger than its P6 counterpart as a possible candidate biomarker. We conclude by visually mapping FPN integration existent in healthy controls, yet absent in AD patients during cross-modal memory tasks. The implications and limitations of these findings are discussed, as are foundations for future research in exploring processes and strategies that lead to identifying clinically useful biomarkers for the detection and treatment of AD.

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Section: The Frontoparietal Network (Fpn)mentioning

confidence: 94%

Evaluating Frontoparietal Network Topography for Diagnostic Markers of Alzheimer’s Disease

Rogers

2024

Preprint

View full text Add to dashboard Cite

show abstract

Evaluating frontoparietal network topography for diagnostic markers of Alzheimer’s disease

Rogers

2024

Sci Rep

View full text Add to dashboard Cite

Numerous prospective biomarkers are being studied for their ability to diagnose various stages of Alzheimer’s disease (AD). High-density electroencephalogram (EEG) methods show promise as an accurate, economical, non-invasive approach to measuring the electrical potentials of brains associated with AD. Event-related potentials (ERPs) may serve as clinically useful biomarkers of AD. Through analysis of secondary data, the present study examined the performance and distribution of N4/P6 ERPs across the frontoparietal network (FPN) using EEG topographic mapping. ERP measures and memory as a function of reaction time (RT) were compared between a group of (n = 63) mild untreated AD patients and a control group of (n = 73) healthy age-matched adults. Based on the literature presented, it was expected that healthy controls would outperform patients in peak amplitude and mean component latency across three parameters of memory when measured at optimal N4 (frontal) and P6 (parietal) locations. It was also predicted that the control group would exhibit neural cohesion through FPN integration during cross-modal tasks, thus demonstrating healthy cognitive functioning consistent with older healthy adults. By targeting select frontal and parietal EEG reference channels based on N4/P6 component time windows and positivity, our findings demonstrated statistically significant group variations between controls and patients in N4/P6 peak amplitudes and latencies during cross-modal testing. Our results also support that the N4 ERP might be stronger than its P6 counterpart as a possible candidate biomarker. We conclude through topographic mapping that FPN integration occurs in healthy controls but is absent in AD patients during cross-modal memory tasks.

show abstract

Working Memory Capacity and the Cognitive Underpinnings of Syntactic Processing

Abstract: Working Memory Capacity and the Cognitive Underpinnings of Syntactic Processing

Cited by 2 publications

References 15 publications

Evaluating Frontoparietal Network Topography for Diagnostic Markers of Alzheimer’s Disease

Evaluating Frontoparietal Network Topography for Diagnostic Markers of Alzheimer’s Disease

Evaluating frontoparietal network topography for diagnostic markers of Alzheimer’s disease

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