Working memory function in post-traumatic stress disorder: An event-related potential study

Veltmeyer, Melinda D.; Clark, C. Richard; McFarlane, Alexander C.; Moores, Kathryn A.; Bryant, Richard A.; Gordon, Evian

doi:10.1016/j.clinph.2009.03.024

Cited by 23 publications

(23 citation statements)

References 40 publications

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“…[59][60][61] Research using other tasks and imaging techniques has also documented abnormal activity in the right prefrontal cortices of patients with PTSD, 8,48,49,62 and considerable research has demonstrated that symptoms of PTSD, such as cognitive control deficits, correlate with differences in prefrontal neural activity. 7,[63][64][65] A recent meta-analysis of neurocognitive functioning in PTSD also suggested that frontal regions are critical to the pathophysiology of PTSD, as the largest effect sizes were found for verbal learning, attention/ working memory and speed of information processing. 10 Our results concur with this view, providing important temporal and localization information suggesting that aberrations in working memory processing emerge within 200 ms after stimulus onset in the right prefrontal regions, spread to the right supramarginal and temporal cortices and largely continue throughout both the encoding and maintenance phases.…”

Section: Working Memory Encoding and Maintenance Deficits In Veteransmentioning

confidence: 99%

Male veterans with PTSD exhibit aberrant neural dynamics during working memory processing: an MEG study

McDermott

Badura-Brack

Becker

et al. 2016

jpn

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IntroductionPosttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by re-experiencing, avoidance, negative alterations in mood and cognition, and physiologic arousal symptoms, which may develop subsequent to a traumatic event (e.g., combat).1,2 The lifetime prevalence of PTSD in the United States is roughly 7%-9%; 3,4 however, prevalence rates among recent combat veterans are estimated at 13%-22%. 5,6 Previous studies have demonstrated that patients with PTSD experience deficits in memory, attention and executive functioning. [7][8][9] More specifically, a recent meta-analysis of 60 neurocognitive studies comparing patients with PTSD to healthy controls (4108 participants) found the largest effect sizes reflecting deficiencies in the PTSD group for verbal learning, information processing speed and attention/working memory. 10 The etiology of these functional deficits is not entirely clear, but they do appear to be contributing factors to PTSD symptomatology. 11,12Working memory is an essential component of information processing and is typically divided into 3 cognitive subprocesses: encoding, maintenance and retrieval.13 Studies using functional magnetic resonance imaging (fMRI) and positron emission tomography 14 have identified the network architecture serving working memory processing in healthy adults. Critical brain regions include the prefrontal cortex, superior parietal lobule and adjacent areas, lateral occipital regions, cerebellum, and the left supramarginal gyrus and contiguous temporal regions.14,15 While such studies elucidate brain regions responsible for general working memory function, they rely on indirect measures of brain activity (e.g., local blood oxygenation), making it difficult to dissociate which areas are active during each phase of working memory. Background: Posttraumatic stress disorder (PTSD) is associated with executive functioning deficits, including disruptions in working memory. In this study, we examined the neural dynamics of working memory processing in veterans with PTSD and a matched healthy control sample using magnetoencephalography (MEG). Methods: Our sample of recent combat veterans with PTSD and demographically matched participants without PTSD completed a working memory task during a 306-sensor MEG recording. The MEG data were preprocessed and transformed into the time-frequency domain. Significant oscillatory brain responses were imaged using a beamforming approach to identify spatiotemporal dynamics. Results: Fifty-one men were included in our analyses: 27 combat veterans with PTSD and 24 controls. Across all participants, a dynamic wave of neural activity spread from posterior visual cortices to left frontotemporal regions during encoding, consistent with a verbal working memory task, and was sustained throughout maintenance. Differences related to PTSD emerged during early encoding, with patients exhibiting stronger α oscillatory responses than controls in the right inferior frontal gyrus (IFG). Differences spread to the right supramarginal ...

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Section: Working Memory Encoding and Maintenance Deficits In Veteransmentioning

confidence: 99%

Male veterans with PTSD exhibit aberrant neural dynamics during working memory processing: an MEG study

McDermott

Badura-Brack

Becker

et al. 2016

jpn

View full text Add to dashboard Cite

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“…A second variant of P3, which we have labelled P3wm on the basis of two prior studies (Galletly, McFarlane, & Clark, 2008;Veltmeyer, McFarlane, Moores, Bryant, & Gordon, 2009), is elicited in the context of the Two In A Row (TIAR) task. P3wm is thought to reflect the processes that occur when information is maintained and updated in working memory.…”

Section: Manual Of Mental Disorders -V (Dsm -V) Classification Of Sommentioning

confidence: 99%

“…P3wm is thought to reflect the processes that occur when information is maintained and updated in working memory. The amplitude of P3 in this context has been shown to differentiate people with PTSD and schizophrenia from controls (Galletly, et al, 2008;Veltmeyer, et al, 2009), and we were interested in whether people with somatic hypervigilance, often associated with PTSD, also produced an altered performance on this task. P3wm is typically measured at central parietal sites and a higher amplitude reflects the resources allocated to task performance (Saliasi, Geerligs, Lorist, & Maurits, 2013).…”

Section: Manual Of Mental Disorders -V (Dsm -V) Classification Of Sommentioning

confidence: 99%

A case-matched study of neurophysiological correlates to attention/working memory in people with somatic hypervigilance

Berryman

Wise

Stanton

et al. 2016

Journal of Clinical and Experimental Neuropsychology

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The AM is defined by the National Information Standards Organization as: "The version of a journal article that has been accepted for publication in a journal."This means the version that has been through peer review and been accepted by a journal editor. When you receive the acceptance email from the Editorial Office we recommend that you retain this article for future posting.Embargoes apply if you are posting the AM to an institutional or subject repository, or to academic social networks such as Mendeley, ResearchGate, or Academia.edu. Embargo Journal of Clinical and Experimental Neuropsychology

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“…Some studies indicated changes in P300 characteristics in patients with Parkinson's disease (the changes correlated with the degree of the disease determined according to the Hoehn and Yahr scale), growth hormone deficiency, Huntington's disease, Tourette syndrome, and narcolepsy (2,9,(24)(25)(26)(27). Changes of P300 characteristics, lowered amplitude, and extended latency have also been noticed in schizophrenia (28)(29)(30)(31)(32)(33)(34)(35)(36), post-traumatic stress disorder (36,37,40), endogenous psychoses (38)(39)(40)(41), panic disorder (42)(43)(44)(45), and depressive patients (46,47). Additionally, a few papers described changes of P300 in impulsive aggressive criminals and obsessive-compulsive disorder (48,49).…”

Section: Review Of Literaturementioning

confidence: 99%

P300 as an auxiliary method in clinical practice: A review of literature

Titlić

Mihalj

Petrovic

et al. 2016

JHSCI

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Cognitive functions can be assessed and followed up over a period of time with cognitive evoked potentials (CEP) P300� In this context, brainstem auditory evoked potentials (BAEP) are most commonly used, but visual evoked potentials (VEP) are utilized as well� The research in this area has demonstrated that these techniques could be used as a supplemental method in diagnostics of numerous diseases such as Alzheimer's disease, mild cognitive impairment, vascular dementia, epilepsy, craniocerebral trauma, Parkinson's disease, multiple sclerosis, and other degenerative diseases� In addition, P300 can also be used as an auxiliary method in the diagnostics of mental disorders conditions such as schizophrenia, panic disorders, narcotic drug addiction, nicotinism, alcoholism, etc� The method assists in monitoring the course of diseases leading to encephalopathy, such as liver and kidney damage and grave anaemia� The advantages of P300 testing are easy application, non-invasiveness, and an unlimited number of potential applications� Moreover, the results obtained with this method are measurable and can be compared�

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Working memory function in post-traumatic stress disorder: An event-related potential study

Cited by 23 publications

References 40 publications

Male veterans with PTSD exhibit aberrant neural dynamics during working memory processing: an MEG study

Male veterans with PTSD exhibit aberrant neural dynamics during working memory processing: an MEG study

A case-matched study of neurophysiological correlates to attention/working memory in people with somatic hypervigilance

P300 as an auxiliary method in clinical practice: A review of literature

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