Working memory in mild cognitive impairment and Alzheimer's disease: Contribution of forgetting and predictive value of complex span tasks.

Abstract

Overall, these results indicate impaired WM in age-related disorders with a gradient between MCI and AD. Retention interval increases deficit in persons with AD. It also shows potential in predicting a negative prognosis in those with MCI.

Alzheimer’s disease and Type 2 Diabetes Mellitus: Similar Memory and Executive Functions Impairments?

“…Executive control assessed with the Wisconsin Card Sorting Test (WCST) showed similar declines in both groups of patients. These results were in line with previous AD studies [24,[31][32][33][34] and with other T2DM studies [35][36][37]. Neuropsychologists use the WCST to assess the integrity of frontal lobe functions and perseveration in the same response is interpreted as a failure of the executive control function.…”

Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals

“…Although early and significant episodic memory impairment constitutes the clinical core diagnostic criterion of AD (Dubois et al, 2014), there is increasing evidence of early deficits in WM and executive function in patients with MCI and AD (Crawford et al, 2013;Gagnon and Belleville, 2011;Huntley and Howard, 2010;Kessels et al, 2011;Koppel et al, 2014). Moreover, fMRI studies have also suggested a possible subclinical impairment of WM capacity in healthy APOE ε4 carriers (Chen et al, 2013).…”

Training of attentional control in mild cognitive impairment with executive deficits: Results from a double-blind randomised controlled study

“…It is generally agreed that attentional control relies on a set of distinct capacities including inhibition, switching and divided attention (Baddeley, 1996;Miyake, Friedman, Emerson, Witzki, & Howerter, 2000). Testing the efficacy of attentional intervention in MCI is first justified by the presence of attentional control deficits in early AD (Baddeley, Baddeley, Bucks, & Wilcock, 2001;Belleville, Peretz, & Malenfant, 1996;Belleville, Rouleau, Van der Linden, & Colette, 2003;Colette, Van der Linden, & Salmon, 1999;Greene, Hodges, & Baddeley, 1995;Logie, Cocchini, Della Sala, & Baddeley, 2004;Perry, Watson, & Hodges, 2000) and in MCI (Belanger, Belleville, & Gauthier, 2010;Belleville, Chertkow, & Gauthier, 2007;Borkowska, Drożdż, Jurkowski, & Rybakowski, 2009;Gagnon & Belleville, 2011). Second, improving attentional control might have long-range effects beyond traditional executive tasks or capacities.…”