Working memory in schizophrenia and mania: correlation with symptoms during the acute and subacute phases

McGrath, John J.; Chapple, Ben; Wright, Margaret J.

doi:10.1034/j.1600-0447.2001.00114.x

Cited by 77 publications

(58 citation statements)

References 41 publications

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“…First, although patients with BP and SCZ showed similar deficits of working memory in this study as in previous studies (Hill et al, 2008;McGrath et al, 2001), it does not necessarily mean that both diseases have the same neural basis for their impaired working memory. A recent meta-analysis of studies on SCZ patients revealed decreased activity in the DLPFC, reflecting disrupted frontal-based top-down control functions, but increased activity in the VLPFC, suggesting a compensatory response (Minzenberg et al, 2009).…”

Section: Discussionmentioning

confidence: 46%

The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder

Zhang

Shen

et al. 2011

Neuropsychopharmacol

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Section: Discussionmentioning

confidence: 46%

The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder

Zhang

Shen

et al. 2011

Neuropsychopharmacol

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“…McGrath et al procuraram investigar se as dificuldades cognitivas na esquizofrenia e na mania seriam semelhantes em tarefa que avaliava a memória de trabalho e notaram que os dois grupos apresentavam prejuízos em relação a esta função, sendo estes correlacionados à presença de sintomas positivos e negativos. 53 Liu et al e Addington e Addington verificaram que pacientes esquizofrênicos possuíam dificuldades mais acentuadas do que os bipolares com ou sem características psicóticas em uma medida de atenção sustentada.…”

Section: -51unclassified

Alterações neuropsicológicas no transtorno bipolar

Rocca

Lafer

2006

Rev. Bras. Psiquiatr.

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Alterações neuropsicológicas no transtorno bipolar Neuropsychological disturbances in bipolar disorderResumo Objetivo: Revisão sistemática dos estudos controlados publicados nos últimos 15 anos sobre alterações neuropsicológicas no transtorno bipolar. Método: Foi realizado um levantamento bibliográfico no Medline, Lilacs, PubMed e ISI, selecionando-se o período de 1990 a 2005. Os estudos foram organizados a partir da comparação entre a amostra selecionada (bipolar versus outra patologia versus controles saudáveis). Nós só incluímos estudos controlados e com uma amostra de pacientes maior que 10, totalizando 73 artigos, do quais 53 foram selecionados para esta revisão. Resultados: Pacientes com transtorno bipolar apresentam dificuldades em vários domínios cognitivos, sendo que alguns persistem mesmo após remissão dos sintomas. Os déficits encontrados se localizaram basicamente nas funções executivas. Na comparação com pacientes portadores de esquizofrenia, os bipolares apresentam perfil de alterações cognitivas mais leves, o que aponta para diferenças em termos de prognóstico da doença e para anormalidades em circuitos neuroanatômicos específicos. Houve correlação positiva entre déficits cognitivos e número de episódios ou internações. As medicações utilizadas para estabilização do humor podem ter um impacto negativo na cognição. Conclusões: Os prejuízos são sugestivos de disfunção em circuitos fronto-estriatais específicos que podem, em parte, explicar as dificuldades na adaptação psicossocial destes pacientes. Estudos futuros devem avaliar a eficácia de programas de reabilitação neuropsicológica, os quais visam, por meio de treinos cognitivos, minimizar o impacto dos déficits encontrados na vida diária dos pacientes. Descritores: Transtorno bipolar; Neuropsicologia; Estudos de avaliação; Transtornos cognitivos; Processos mentaisA b s t r a c t Objective: Systematic literature review of the controlled studies published in the last 15 years on neuropsychological deficits in Bipolar Disorder. Method: Bibliographical research was completed through Medline, Lilacs, PubMed and ISI, speciafically for 1990 to 2005 period. Selected studies were organized beginning with the comparison among the selected sample (bipolar versus other pathology versus control healthy). We included only controlled studies with a patient sample larger than 10, and 73 papers were found, being that 53 selected for this systematic review. Results: Patients with Bipolar Disorder present difficulties in several cognitive domains which partially persist even after acute episodes acute episodes. The deficits impaired basically the executive functions. When compared to schizophrenia, bipolar patients present milder deficits in the neuropsychological tests, which may explain differences in terms of disease outcome and specific circuitry abnormalities. There was a positive correlation between cognitive deficits and number of episodes or hospitalizations. The medications used for mood stabilization can produce a negative impact on cognition. Conclusions...

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“…[34][35][36][37][38] For example, working memory has been shown to improve following recovery of acute psychosis in both conditions. 37 …”

Section: Cognitive Impairment and Clinical Statementioning

confidence: 99%

Cognitive Impairment in Schizophrenia and Affective Psychoses: Implications for DSM-V Criteria and Beyond

Bora¹,

Yücel²,

Pantelis³

2009

Schizophrenia Bulletin

247

124

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It has recently been suggested that the diagnostic criteria of schizophrenia should include specific reference to cognitive impairments characterizing the disorder. Arguments in support of this assertion contend that such inclusion would not only serve to increase the awareness of cognitive deficits in affected patients, among both clinicians and researchers alike, but also increase the ''point of rarity'' between schizophrenia and mood disorders. The aim of the current article is to examine this latter assertion in light of the recent opinion piece provided by Keefe and Fenton (Keefe RSE, Fenton WS. How should DSM-V criteria for schizophrenia include cognitive impairment? Schizophr Bull. 2007;33:912-920). Through literature review, we explore the issue of whether cognitive deficits do in fact differentiate the major psychoses. The overall results of this inquiry suggest that inclusion of cognitive impairment criteria in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-V) would not provide a major advancement in discriminating schizophrenia from bipolar disorder and affective psychoses. Therefore, while cognitive impairment should be included in DSM-V, it should not dictate diagnostic specificity-at least not until more comprehensive evidence-based reviews of the current diagnostic system have been undertaken. Based on this evidence, we consider several alternatives for the DSM-V definition of cognitive impairment in schizophrenia, including (1) the inclusion of cognitive impairment as a specifier and (2) the definition of cognitive impairment as a dimension within a hybrid categorical-dimensional system. Given the state of current evidence, these possibilities appear to represent the most parsimonious approaches to the inclusion of cognitive deficits in the diagnostic criteria of schizophrenia and, potentially, of mood disorders.

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Working memory in schizophrenia and mania: correlation with symptoms during the acute and subacute phases

Abstract: Impaired working memory is found in both schizophrenia and mania during the acute subacute phases. Further research is required in order to clarify the neurocognitive mechanisms linking impaired working memory with both negative symptoms and positive thought disorder.

Cited by 77 publications

References 41 publications

The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder

The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder

Alterações neuropsicológicas no transtorno bipolar

Cognitive Impairment in Schizophrenia and Affective Psychoses: Implications for DSM-V Criteria and Beyond

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