During the loading process, significant external position disturbances occur in the electro–hydraulic load simulation system. To address these position disturbances and effectively mitigate the impact of uncertainty on system performance, this paper first treats model parameter uncertainty and external disturbances as lumped disturbances. The various states of the servo valve and the pressures within the hydraulic cylinder chambers are then examined. Building on this foundation, the paper proposes a nonlinear multi-mode variable structure independent load port electro–hydraulic load simulation system that is tailored for specific loading conditions. Secondly, in light of the significant motion disturbances present, this paper proposes an integral sliding mode active disturbance rejection composite control strategy that is based on fixed-time convergence. Based on the structure of the active disturbance rejection control framework, the fixed-time integral sliding mode and active disturbance rejection control algorithms are integrated. An extended state observer is designed to accurately estimate the lumped disturbance, effectively compensating for it to achieve precise loading of the independent load port electro–hydraulic load simulation system. The stability of the designed controller is also demonstrated. The results of the simulation research indicate that when the command input is a step signal, the pressure control accuracy under the composite control strategy is 99.94%, 99.86%, and 99.76% for disturbance frequencies of 1 Hz, 3 Hz, and 5 Hz, respectively. Conversely, when the command input is a sinusoidal signal, the pressure control accuracy remains high, measuring 99.94%, 99.8%, and 99.6% under the same disturbance frequencies. Furthermore, the simulation demonstrates that the influence of sensor random noise on the system remains within acceptable limits, highlighting the effective filtering capabilities of the extended state observer. This research establishes a solid foundation for the collaborative control of load ports and the engineering application of the independent load port electro–hydraulic load simulation system.