Working title: Molecular involvement of p53‐MDM2 interactome in gastrointestinal cancers
Poornachandra Yedla,
Pranav Bhamidipati,
Riyaz Syed
et al.
Abstract:The interaction between murine double minute 2 (MDM2) and p53, marked by transcriptional induction and feedback inhibition, orchestrates a functional loop dictating cellular fate. The functional loop comprising p53‐MDM2 axis is made up of an interactome consisting of approximately 81 proteins, which are spatio‐temporally regulated and involved in DNA repair mechanisms. Biochemical and genetic alterations of the interactome result in dysregulation of the p53‐mdm2 axis that leads to gastrointestinal (GI) cancers… Show more
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