Aims: The purpose of this study was to investigate the relationship between nurses’ perceived organizational support, work well‐being, and medical narrative ability.Background: With the proposed bio‐psycho‐social medical model, nurses’ medical narrative ability is closely related to patients’ health problems and quality of life. Nurses’ perceived organizational support and work well‐being can improve nurses’ empathy and reflection ability to a certain extent and promote patients’ rehabilitation. However, the relationship between nurses’ perceived organizational support, work well‐being, and medical narrative ability is unclear.Methods: A total of 1831 nurses from 8 hospitals in China were surveyed using an online questionnaire that included nurses’ sociodemographic, perceived organizational support, work well‐being, and medical narrative ability. IBM SPSS 27.0 was used for Pearson’s correlation analysis, one‐way ANOVA, t‐test, and mediation effect analysis using Model 4 in PROCESS (5000 resamples).Results: The total mean score of perceived organizational support (46.68 ± 11.00), work well‐being (53.09 ± 10.81), and medical narrative ability (154.48 ± 22.93) among nurses was found to be moderate. The relationship between perceived organizational support, work well‐being, and medical narrative ability was significant, with correlation coefficients ranging from 0.348 to 0.685 (p < 0.01). The relationship between perceived organizational support and medical narrative ability is partially mediated by work well‐being. The intermediate effect accounted for 52.36% of the total effect.Conclusion: This study found that nurses’ work well‐being mediated the relationship between perceived organizational support and medical narrative ability.Implications for Nursing Management: This study evaluated nurses’ medical narrative ability and explored the relationship between nurses’ perceived organizational support, work well‐being, and medical narrative ability. The results of this study can help nursing managers and educators to take appropriate measures to intervene nurses’ perceived organizational support and work well‐being, so as to improve nurses’ medical narrative ability and optimize nursing quality.