2022
DOI: 10.1016/j.waojou.2022.100668
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World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines update - III - Cow's milk allergens and mechanisms triggering immune activation

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Cited by 32 publications
(21 citation statements)
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“…When this site is empty, Bos d 5 promotes the expression of CD4 on helper T cells and increased production of the T2 cytokines IL‐10 and IL‐13 compared to a “loaded” site where there was a decreased CD4+ expression 38,39 . It was previously hypothesized that milk processing alters the hydrophobic binding site on Bos d 5 making it more immunogenic 40,41 . Further studies are needed to examine the potential‐specific role of Bos d 5 since this seems to be the dominant antigenic component of cow's milk and more than half of EoE patients respond to cow's milk protein elimination diet 18 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…When this site is empty, Bos d 5 promotes the expression of CD4 on helper T cells and increased production of the T2 cytokines IL‐10 and IL‐13 compared to a “loaded” site where there was a decreased CD4+ expression 38,39 . It was previously hypothesized that milk processing alters the hydrophobic binding site on Bos d 5 making it more immunogenic 40,41 . Further studies are needed to examine the potential‐specific role of Bos d 5 since this seems to be the dominant antigenic component of cow's milk and more than half of EoE patients respond to cow's milk protein elimination diet 18 …”
Section: Discussionmentioning
confidence: 99%
“…38,39 It was previously hypothesized that milk processing alters the hydrophobic binding site on Bos d 5 making it more immunogenic. 40,41 AutoSTOMP is a novel technology that allows for spatial analysis of the proteome surrounding IgG4 deposits in the esophagus.…”
Section: Discussionmentioning
confidence: 99%
“…Another intriguing result concerned the lack of the OIT effect on allergen-specific IgE in milk molecules. OIT probably acts on tolerogenic mechanisms, independent from a type 2 response, but involving Breg and Treg cells as actors of natural immunotolerance [ 31 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…CMPA affects approximately 8%of infants and young children. After egg, peanut, and fish allergies, it is the fourth-most common food allergy in babies [4].…”
Section: Introductionmentioning
confidence: 99%
“…A variety of factors may play a role in the complex development of food allergies. A disruption in the development of oral tolerance has been observed in infants with food allergies, characterized by defects in the induction of regulatory T cells, and the production of allergen-specific neutralizing IgA antibodies [4]. Furthermore, even though the specific properties of the allergens themselves contribute to the degree of allergenicity, defects in the epithelial barrier, both in the skin and in the intestine, as well as changes in the pH of the stomach are thought to promote allergy.…”
Section: Introductionmentioning
confidence: 99%