World health organization releases global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics

Shrivastava, Saurabh RamBihariLal; Shrivastava, Prateek Saurabh; Ramasamy, Jegadeesh

doi:10.4103/jms.jms_25_17

Cited by 364 publications

(257 citation statements)

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“…According to the Regulation of the Minister of Health, they are the first on the current list of "alarm pathogens" (1). The importance of this international problem is emphasized by the fact that world-class experts at the World Health Organization, during a meeting in Geneva in February 2017, decided to place MRSA strains on the global priority pathogens list (global PPL) of antibioticresistant bacteria, which includes twelve most dangerous pathogens posing a threat to public health (2,3).…”

Section: Methicillin-resistantmentioning

confidence: 99%

“…Zgodnie z Rozporządzeniem Ministra Zdrowia, znajdują się na pierwszym miejscu obowiązującej listy "patogenów alarmowych" (1). Rangę problemu na skalę międzynarodową podkreśla fakt, iż światowej klasy eksperci World Health Organization, podczas spotkania w Genewie w lutym 2017 roku zdecydowali o umieszczeniu szczepów MRSA na liście dwunastu najbardziej niebezpiecznych patogenów "global priority pathogens list (global PPL) of antibiotic-resistant bacteria", stanowiących zagrożenie dla zdrowia publicznego (2,3).…”

Section: Methicillin-resistantunclassified

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Prevalence of methicillin resistant and mupirocin-resistant Staphylococcus aureus strains among medical students of Medical University in Warsaw

et al. 2019

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INTRODUCTION.Staphylococcus aureus is a microorganism, which is able to colonize the human body without any pathogenic effect, but it also can cause life-threatening infections (opportunistic pathogen). Asymptomatic colonization with both methicillin resistant (MRSA) and methicillin susceptible (MSSA) S.aureus strains state is an important predisposing factor for infections. The risk of infection for carriers of MSSA is even three-times higher than for non-colonized people, and in the case of MRSA it is even four-times higher than in MSSA carriers. Carriers can be also a source of infection for other people, especially those belonging to high-risk groups. The drug of choice used for the local eradication of S.aureus is mupirocin (Mup). In recent years, the failure of decolonization therapy has been observed. The aim of the study was to assess and compare the level of colonization of S.aureus (MRSA or MSSA) among medical students and to evaluate the sensitivity of the strains to mupirocin. For MRSA/MupRSA isolates the molecular mechanism of resistance phenotype was determined. MATERIALS AND METHODS. 955 swabs from 2014-2016 from pre-clinical students of medicine of the Medical University of Warsaw. The strains were identified using Pastorex-Staph-Plus (BioRad) and/or the VITEK-MS system (Biomerieux), according to manufacturer's instructions. Susceptibility to methicillin and mupirocin was determined by disk diffusion and/or broth microdilution method, according to EUCAST. The presence of the mecA/mecC and mupA genes were detected with PCR technique. RESULTS. Asymptomatic colonization with S.aureus strains was found in 245/955 (25,7%) students, in particular years in the range of 21,7-29,9%. 243 isolates expressed the MSSA/MupSSA phenotype, one strain was resistant to mupirocin MSSA/MupRSA (genotype mecA/mecC-negative, mupA-positive) and one showed simultaneous resistance to methicillin and mupirocin (mecA/mupA-positive genotype). The level of MRSA and MupRSA colonization was 0,1% and 0,2%, respectively. SUMMARY AND CONCLUSIONS. The level of S.aureus colonization among surveyed students, didn't differ from the norm for a generally healthy population, but showed an upward trend. The carriage of S.aureus, especially of multi-resistant strains among medical students at the beginning of their clinical activities, consist of a real threat to patients and other people.

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Section: Methicillin-resistantmentioning

confidence: 99%

Section: Methicillin-resistantunclassified

Prevalence of methicillin resistant and mupirocin-resistant Staphylococcus aureus strains among medical students of Medical University in Warsaw

et al. 2019

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“…Infections caused by multidrug-resistant (MDR) Gram-negative and Gram-positive bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter, Staphylococcus spp., and Enterococcus spp. represent an increasing worldwide problem [1]. Currently, the appearance of MDR bacteria makes it impossible to find an effective drug to treat certain infectious diseases [2].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Colloidal Silver against Gram-Negative and Gram-Positive Bacteria

et al. 2020

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Due to the emergence of antimicrobial resistance, new alternative therapies are needed. Silver was used to treat bacterial infections since antiquity due to its known antimicrobial properties. Here, we aimed to evaluate the in vitro activity of colloidal silver (CS) against multidrug-resistant (MDR) Gram-negative and Gram-positive bacteria. A total of 270 strains (Acinetobacter baumannii (n = 45), Pseudomonas aeruginosa (n = 25), Escherichia coli (n = 79), Klebsiella pneumoniae (n = 58)], Staphylococcus aureus (n = 34), Staphylococcus epidermidis (n = 14), and Enterococcus species (n = 15)) were used. The minimal inhibitory concentration (MIC) of CS was determined for all strains by using microdilution assay, and time–kill curve assays of representative reference and MDR strains of these bacteria were performed. Membrane permeation and bacterial reactive oxygen species (ROS) production were determined in presence of CS. CS MIC90 was 4–8 mg/L for all strains. CS was bactericidal, during 24 h, at 1× and 2× MIC against Gram-negative bacteria, and at 2× MIC against Gram-positive bacteria, and it did not affect their membrane permeabilization. Furthermore, we found that CS significantly increased the ROS production in Gram-negative with respect to Gram-positive bacteria at 24 h of incubation. Altogether, these results suggest that CS could be an effective treatment for infections caused by MDR Gram-negative and Gram-positive bacteria.

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“…The real incidence of pathogenic causes could be underestimated [18]. This spread of Gram-negative bacteria resistance to carbapenems is an urgent public threat and a critical priority according to World Health Organisation [20].…”

Section: Original Research Articlementioning

confidence: 99%

Clinical and microbiological profile of health care associated pneumonia in patients with chronic renal disease referred to a tertiary care hospital- a prospective study

Rao

Subhankar

Patnaik

et al. 2019

Trop J Pathol Microbiol

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Background: Healthcare associated pneumonia (HCAP) is a public health problem in the era of home care of chronic illness including chronic renal disease. They have greater burden of comorbidities, immune suppression and impaired mobility. Aim of the Study: To characterise the clinical, radiological and microbiological profile of health care associated pneumonia in chronic renal disease cases including its resistance pattern and outcome in the study population. Materials and Methods: This prospective study was conducted among patients with chronic kidney disease (CKD) who had been treated in multiple hospitals across Odisha. They were subjected to history taking, clinical examination, laboratory and radiological investigations. Sputum or endotracheal tube culture were sent for gram stain and aerobic culture. All the categorical parameters were compared using Fisher's exact test. Continuous parameters were compared using independent t-test. All the statistical analysis was carried out using the software Stata 15.1. A p-value less than 0.05 was considered significant. Results: 58 patients with an underlying chronic kidney disease were included. 54 (93.1%%) patients survived while 4 (6.9%) died. The mean age, total leucocyte count and serum urea levels were higher among patients who died in comparison to the survivors (p= 0.95, 0.334 and 0.386 respectively). Klebsiella spp (12.07%), and Acinetobacter (8.6%) were most commonly isolated. Multi-drug resistance (MDR) and extensive drug resistance (XDR) were encountered among these organisms. Death was more commonly associated in patients ≥60yrs (p= 1), TLC ≥ 11000 cells/mm3 (p= 0.0091), serum creatinine ≥ 3mg/dl (p= 0.329) and radiological involvement of ≥ 3zones (p= 1). Conclusion: CKD is an important contributor in HCAP. Data from different institutions to corroborate our findings regarding antibiotic resistance pattern of the microbes in HCAP cases is recommended.

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World health organization releases global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics

Cited by 364 publications

References 0 publications

Prevalence of methicillin resistant and mupirocin-resistant Staphylococcus aureus strains among medical students of Medical University in Warsaw

Prevalence of methicillin resistant and mupirocin-resistant Staphylococcus aureus strains among medical students of Medical University in Warsaw

Antibacterial Activity of Colloidal Silver against Gram-Negative and Gram-Positive Bacteria

Clinical and microbiological profile of health care associated pneumonia in patients with chronic renal disease referred to a tertiary care hospital- a prospective study

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