World Meningitis Day and the World Health Organization’s roadmap to defeat bacterial meningitis in the COVID-19 pandemic era

Pinto, Tatiana Castro Abreu; Costa, Natália Silva; Oliveira, Laura Maria Andrade

doi:10.1016/j.ijid.2021.04.070

Cited by 4 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2020, the World Health Organization endorsed a global road map that sets forth a vision to defeat meningitis by 2030. The road map sets three goals towards a “world free of meningitis”, including the elimination of bacterial meningitis epidemics, reduction of vaccine-preventable bacterial meningitis cases by 50% and deaths by 70%, and reduction of disability and improvement of quality of life among survivors [ 4 , 5 ]. Lessons learned from the COVID-19 pandemic indicate that global cooperation is essential for improving surveillance, diagnosis, and prevention of a global public health threat [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Invasive Disease Due to Neisseria meningitidis: Surveillance and Trends in Israel Prior to and during the COVID-19 Pandemic

Stein-Zamir,

Shoob,

Abramson

et al. 2023

Microorganisms

View full text Add to dashboard Cite

Invasive meningococcal disease (IMD) is a devastating disease with significant mortality and long-term morbidity. The COVID-19 pandemic and containment measures have affected the epidemiology of infectious pathogens. This study’s aim was to assess IMD trends in Israel prior to and during the COVID-19 pandemic. The Neisseria meningitidis invasive infection is a notifiable disease in Israel. Laboratory analysis includes serogrouping and molecular characterization. The overall national IMD incidence rate (1998–2022) was 0.8/100,000 population. The IMD incidence rates declined during the pandemic years (0.3/100,000 in 2020–2022 vs. 0.9/100,000 in 1998–2019). The number of notified IMD cases declined by 65% in 2020–2022. The case fatality rate among laboratory-confirmed IMD cases was 9% (47/521, 2007–2022). Mortality risk markers included cases’ age (older) and socio-economic status (lower). Overall, most Neisseria meningitidis isolates were of serogroup B (62.6%), and the most prevalent clonal complex (CC) was CC32 (24.2%). Serogroup B prevailed in cases aged 0–9 years (74.5%) and less in cases aged 10 years and above (39%). Neisseria meningitidis serogroups and CC distribution altered recently with a decline in serogroup B fraction, an increase in serogroup Y, and a decline in CC32. Ongoing IMD surveillance is necessary to assess trends in circulating strains and support decision-making on meningococcal vaccination programs.

show abstract

Section: Introductionmentioning

confidence: 99%

Invasive Disease Due to Neisseria meningitidis: Surveillance and Trends in Israel Prior to and during the COVID-19 Pandemic

Stein-Zamir,

Shoob,

Abramson

et al. 2023

Microorganisms

View full text Add to dashboard Cite

show abstract

“…Bacterial meningitis represents a public health challenge with a high case fatality rate (CFR) and complications that may include permanent sequelae [ 1 , 2 ]. Although it can be caused by several types of bacteria, Streptococcus pneumoniae , Haemophilus influenzae , and Neisseria meningitidis are the predominant pathogens [ 3 ]. The incidence and mortality rates for bacterial meningitis vary by region and age group [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019

Parellada

Abreu²,

Birck³

et al. 2023

Vaccines

View full text Add to dashboard Cite

The pneumococcal conjugate vaccination (PCV) was introduced into the Brazilian Childhood National Immunization Program in 2010; however, universal pneumococcal vaccination for older adults has not been implemented yet. Our aim is to evaluate the trends in pneumococcal meningitis incidence and case fatality rate (CFR) across all age groups from 2007 to 2019 using data from the National Surveillance System. The pre-PCV (2007–2009) and post-PCV (2011–2019) periods were compared; changes in incidence and CFR were assessed by joinpoint regression. Additional analyses of bacterial meningitis were performed to compare the patterns and trends. Over the 13-year period, 81,203 and 13,837 cases were classified as bacterial and pneumococcal meningitis, respectively. S. pneumoniae was the main etiological agent of bacterial meningitis in adults aged ≥50 years and the most lethal in all age groups. In the post-PCV period, a 56.5% reduction in the average incidence was seen in pneumococcal meningitis in the pediatric population. In contrast, there was an increasing trend among adults. The CFR for pneumococcal and bacterial meningitis remained stable in most age groups during the study period. These findings highlight the value of expanding pneumococcal vaccination policies, including vaccines that provide better indirect protection from children to adults and broadening vaccination to older adults.

show abstract

“…Centers for disease control showed that more than 2.5 million cases and 236,000 deaths are reported due to meningitis in 2019. 3 Mainly children up to 5 years old are suffering from the disease in low and middle-income countries, especially in the meningitis belt of sub-Saharan Africa. 3 Staphylococcus aureus (S. aureus) is a hazardous human pathogen and little is known about its epidemiology as the etiologic agent of meningitis.…”

Section: Introductionmentioning

confidence: 99%

“…3 Mainly children up to 5 years old are suffering from the disease in low and middle-income countries, especially in the meningitis belt of sub-Saharan Africa. 3 Staphylococcus aureus (S. aureus) is a hazardous human pathogen and little is known about its epidemiology as the etiologic agent of meningitis. 4 Circulation of antimicrobial-resistant S. aureus could increase in the community and the burden will be two fold in life threatening diseases such as that of BM.…”

Section: Introductionmentioning

confidence: 99%

Occurrences of self-administered antibiotics, culture diagnostic challenges and multi-drug resistant S. aureus among Ethiopian pyogenic/bacterial meningitis patients: 2020-2021

Mihret

Alemu

Hussein

et al. 2022

Preprint

View full text Add to dashboard Cite

Introduction: Bacterial meningitis (BM) is a serious life-threatening disease affecting the central nervous system. Less focus is given to uncommon causes of BM etiologic agents such as Staphylococcus aureus (S. aureus) and their magnitude of antimicrobial resistance (AMR). The disease burden caused by S. aureus is also poorly understood in developing countries such as Ethiopia. Culture based diagnosis of BM is the gold standard method for detection of the etiologic agents of the disease. Use of self-administered antibiotics results in development of AMR of bacterial agents and in culture based diagnostic challenges.Purpose: This study is exploring the status of uncommon cause of BM, the magnitude of antimicrobial resistance and challenges in culture based diagnosis.Patient and Methods:One hundred thirty-seven patients clinically diagnosed with pyogenic meningitis were recruited from the year 2020 to 2021 from four referral level hospitals located in Ethiopia. Cerebrospinal fluid samples transported in Trans-isolate media (T-IM) was inoculated into blood and culture media plates. Colony morphology and biochemical tests were used for identifying the grown bacterial agents. Patient clinical, socio-demographic and laboratory data were entered into SPSS version 20. Analysis was done using Pearson chi-square test and Graph data set chart builder. Non-parametric test was used to analyze statistical significance of P value < 0.05. Results obtained:A total of seven out of 137 culture media plates have shown growths of colonies on chocolate and blood culture media. Five out of the seven isolates were drug resistant S. aureus while two isolates were Neisseria species which are not drug resistant. Conclusion: Use of self-administered antibiotics prior to hospital visitation may be the reason for culture negative results which are challenges for culture based diagnosis. Wider scope of such studies using sensitive diagnostic approaches such as PCR is recommended to analyze the magnitude of uncommon causes of BM. AMR is occurring even in uncommon BM etiologic agents. Further analysis should be made using PCR amplification of drug resistant genes to bring the issue to public health attention.

show abstract

World Meningitis Day and the World Health Organization’s roadmap to defeat bacterial meningitis in the COVID-19 pandemic era

Cited by 4 publications

References 8 publications

Invasive Disease Due to Neisseria meningitidis: Surveillance and Trends in Israel Prior to and during the COVID-19 Pandemic

Invasive Disease Due to Neisseria meningitidis: Surveillance and Trends in Israel Prior to and during the COVID-19 Pandemic

Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019

Occurrences of self-administered antibiotics, culture diagnostic challenges and multi-drug resistant S. aureus among Ethiopian pyogenic/bacterial meningitis patients: 2020-2021

Contact Info

Product

Resources

About