World’s first en bloc heart-lung transplantation using the paragonix lungguard donor preservation system

Neto, Daniel Messias de Moraes; Guenthart, Brandon A.; Shudo, Yasuhiro; Currie, Morgan

doi:10.1186/s13019-023-02281-7

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…In addition, recent studies examined the effectiveness of LUNGguard (LG) technology, a lung storage device that provides a controlled environment, to determine that the LG storage system can be used as an alternative for lung preservation. 22 , 23 Such advances in preservation techniques also may safely prolong donor lung ischemic time such that the recipient OR time may be delayed until the morning with equivalent outcomes. Given our noninferior findings with standard preservation techniques, the use of newer technology may augment the findings of our prospective study and represents an exciting new direction to further extend recipient start times outside the time frame (1:30 am to 5:00 am ) explored in our study.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of delaying lung transplant surgery to a morning start

Kim,

Xia,

Cho

et al. 2023

JTCVS Open

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of delaying lung transplant surgery to a morning start

Kim,

Xia,

Cho

et al. 2023

JTCVS Open

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“…Conversely, post-transplant outcomes seem to have plateaued across the eras. This issue may be partly resolved with the newly developed innovative organ preservation and transport system, which may positively impact long-term survival in this complex patient population [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Revised Heart Allocation Policy Improved Waitlist Mortality and Waiting Time With Maintained Outcomes in En-Bloc Heart-Lung Transplant Candidates and Recipients

Shudo,

He,

Elde

et al. 2023

Transpl Int

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The revised United Network for Organ Sharing heart allocation policy was implemented in October 2018. Using a national transplant database, this study evaluated the transplant rate, waitlist mortality, waiting time, and other outcomes of en-bloc heart-lung transplantation recipients. Adult patients registered on the national database for heart-lung transplants before and after the policy update were selected as cohorts. Baseline characteristics, transplant rates, waitlist mortality, waiting times, and other outcomes were compared between the two periods. In total, 370 patients were registered for heart-lung transplants during the pre- and post-periods. There were significantly higher transplant rates, shorter waitlist times, and substantially reduced waitlist mortality in the post-period. Registered patients waitlisted in the post-period had significantly higher utilization of intra-aortic balloon pumps, extracorporeal membrane oxygenation, and overall life support, including ventricular assist devices. Transplant recipients had significantly longer ischemic times, increased transport distances, and shorter waiting times before transplantation in the post-policy period. Transplant recipients held similar short-term survival before and after the policy change (log-rank test, p = 0.4357). Therefore, the revised policy significantly improved access to en-bloc heart-lung allografts compared with the prior policy, with better waitlist outcomes and similar post-transplant outcomes.

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“…This was applied to human donors/recipients, which resulted in no incidence of PGD3 at 72 hours post-transplant, and a 100% 30-day survival for their five-patient cohort ( 89 ). This has already been implemented into clinical practice, as the LUNGguard (Paragonix) has been FDA-cleared for lung preservation, allowing precise temperature control between 4-8 degrees Celsius ( 90 – 92 ). Preliminary investigations have demonstrated no significant difference in rates of PGD development when compared to traditional cold storage ( 92 ).…”

Section: Methods Used To Mitigate Pgd and Its Effectsmentioning

confidence: 99%

Donor and recipient risk factors for the development of primary graft dysfunction following lung transplantation

Jenkins,

Verdiner,

Omar

et al. 2024

Front. Immunol.

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Primary Graft Dysfunction (PGD) is a major cause of both short-term and long-term morbidity and mortality following lung transplantation. Various donor, recipient, and technical risk factors have been previously identified as being associated with the development of PGD. Here, we present a comprehensive review of the current literature as it pertains to PGD following lung transplantation, as well as discussing current strategies to mitigate PGD and future directions. We will pay special attention to recent advances in lung transplantation such as ex-vivo lung perfusion, thoracoabdominal normothermic regional perfusion, and up-to-date literature published in the interim since the 2016 ISHLT consensus statement on PGD and the COVID-19 pandemic.

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World’s first en bloc heart-lung transplantation using the paragonix lungguard donor preservation system

Cited by 8 publications

References 17 publications

Safety and efficacy of delaying lung transplant surgery to a morning start

Safety and efficacy of delaying lung transplant surgery to a morning start

Revised Heart Allocation Policy Improved Waitlist Mortality and Waiting Time With Maintained Outcomes in En-Bloc Heart-Lung Transplant Candidates and Recipients

Donor and recipient risk factors for the development of primary graft dysfunction following lung transplantation

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