World Trade Center “Sarcoid-Like” Granulomatous Pulmonary Disease in New York City Fire Department Rescue Workers

Izbicki, Gabriel; Chavko, Robert; Banauch, Gisela I.; Weiden, Michael D.; Berger, Kenneth I.; Aldrich, Thomas K.; Hall, Charles B.; Kelly, Kerry J.; Prezant, David J.

doi:10.1378/chest.06-2114

Cited by 297 publications

(211 citation statements)

References 33 publications

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“…Carbon nanoparticles were found as byproducts of combustion (e.g., diesel, methane, propane, and natural-gas flames of typical stoves) (10,11). In fact, a sarcoidlike disease in firefighters and others was described after exposure to combustion byproducts, and carbon nanoparticles were found postmortem in lung tissue (13)(14)(15)(16). Carbon-based nanomaterials have emerged as a new technology with unique applications in multiple industries, and the use of nanomaterials in consumer products is a rapidly expanding area of manufacturing.…”

mentioning

confidence: 99%

Novel Murine Model of Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes

Huizar

Malur

Midgette

et al. 2011

Am J Respir Cell Mol Biol

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Lung granulomas are associated with numerous conditions, including inflammatory disorders, exposure to environmental pollutants, and infection. Osteopontin is a chemotactic cytokine produced by macrophages, and is implicated in extracellular matrix remodeling. Furthermore, osteopontin is up-regulated in granulomatous disease, and osteopontin null mice exhibit reduced granuloma formation. Animal models currently used to investigate chronic lung granulomatous inflammation bear a pathological resemblance, but lack the chronic nature of human granulomatous disease. Carbon nanoparticles are generated as byproducts of combustion. Interestingly, experimental exposures to carbon nanoparticles induce pulmonary granuloma-like lesions. However, the recruited cellular populations and extracellular matrix gene expression profiles within these lesions have not been explored. Because of the rapid resolution of granulomas in current animal models, the mechanisms responsible for persistence have been elusive. To overcome the limitations of previous models, we investigated whether a model using multiwall carbon nanoparticles would resemble chronic human lung granulomatous inflammation. We hypothesized that pulmonary exposure to multiwall carbon nanoparticles would induce granulomas, elicit a macrophage and T-cell response, and mimic other granulomatous disorders with an up-regulation of osteopontin. This model demonstrates: (1) granulomatous inflammation, with macrophage and T-cell infiltration; (2) resemblance to the chronicity of human granulomas, with persistence up to 90 days; and (3) a marked elevation of osteopontin, metalloproteinases, and cell adhesion molecules in granulomatous foci isolated by laser-capture microdissection and in alveolar macrophages from bronchoalveolar lavage. The establishment of such a model provides an important platform for mechanistic studies on the persistence of granuloma.

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mentioning

confidence: 99%

Novel Murine Model of Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes

Huizar

Malur

Midgette

et al. 2011

Am J Respir Cell Mol Biol

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“…Occupational studies have shown positive associations with service in the U.S. Navy [28] metalworking [27], firefighting [29] and the handling of building supplies [30]. Recently, Izbicki et al reported an increased incidence of sarcoidosis among New York City Fire Department rescue workers involved in the 2001 World Trade Center disaster [31].…”

Section: Environmental Causesmentioning

confidence: 99%

Untitled

2016

JCMK

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Sarcoidosis is a systemic autoimmune disease characterized by noncaseatinggranulomatous inflammation with unknown etiology.Although the lungs and respiratory system are most commonlyinvolved, sarcoidosis may involve virtually any part of the body,including the locomotor system, eyes, skin, lymph nodes. Diagnosis attained via consensus between the clinical presentation and natural history, pattern of major organ involvement, confirmatory biopsy, and response to therapy. Histopathological features remain the gold standard in diagnosis. Radiologic staging in sarcoidosis is based on the chest X-ray. If chest radiographis normal, high-resolution computed tomography (HRCT) can demonstrate pathological changes in a detailed manner. Sarcoidosis generally follows a benign course with occasional spontan remissions. The most important causes of mortality are acute and chronic respiratory failure, pulmonary hypertension and hemoptysis due to aspergillosis. When treatment is indicated, glucocorticoids remain the only recognized effective therapy for active sarcoidosis. Level of evidence for management of sarcoidosis is low, generally reflecting the results of limited number of clinical studies, case series and expert opinion. In selected cases, biological agents including, tumour necrosis factor inhibitors, seem to be promising.Keywords: Sarcoidosis -diagnosis -treatment. Тұжырымдама Саркоидоз, казеозды емес, гранулематозды қабынуымен сипатталатын этиологиясы белгісіз жүйелі аутоиммунды ауру. Өкпе және тыныс алу жүйесінің ең жиі зақымдалуына қарамастан, саркоидоз адам ағзасының кез келген бөлігін, соның ішінде тірек-қимыл жүйесі, көз, тері, лимфа түйіндерін қамтуы мүмкін. Диагноз клиникалық белгілері және шынайы ауру тарихы, ірі мүше зақымдауын растайтын биопсия-сымен, терапияға жауап беру консенсус арқылықоюлуда. Гистопатологиялық ерекшеліктері диагностикада алтын стандарт болып қалуда. Рентгенологиялық зерттеуде кеуде қуысы рентгенографиялық тұрғыдан қалыпты болса, ажыратымдылығы жоғары компьютерлік томогра-фия (HRCT) арқылы егжей-тегжейлі түрде патологиялық өзгерістерін көрсете алады. Саркоидоз, әдетте зарарсыз ағымды, кездейсоқ кенет-тен ремиссиясы кездесетін ауру. Өлімнің ең маңызды себептері жедел және созылмалы тыныс жетіспеушілігі, өкпелік гипертензия, аспер-гиллез салдарынан қан құсу болып табылады. Саркоидоздың белсенді түрінде ең тиімді сапалы ем глюкокортикоидтар болып табылады. Саркоидозды бақылау және басқару үшін дәлелдемелер деңгейінің төмендігін, әдетте, клиникалық зерттеулер, бақылау серияларының және сараптамалық қорытынды саны шектеулі нәтижелерін көрсетеді. Таңдалған жағдайларда ісіктердің некроздық фактор ингибиторлары, оған қоса алғанда, биологиялық агенттері перспективалы болып көрінеді. J Clin Med Kaz 2016; 3(41):6-13Маңызды сөздер: саркоидоз -диагностикасы -емі.Саркоидоз: взгляд терапевта тыназлы М., Бахтиярова г.Клиника Ближневосточного университета, медицинский факультет, кафедра Внутренних болезней, Никосия РезюмеСаркоидоз представляет собой системное аутоиммунное заболевание, характеризу...

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“…Specific occupations prone to being exposed to toxic materials have a higher incidence of sarcoidosis compared to the general population. For example, fire fighters involved in rescue activities during and following the 2001 World Trade Center terrorist attacks have an increased incidence of sarcoidosis [9,11]. The pain in patients with chronic sarcoidosis is often related to neuropathy of the small fibers of the peripheral nervous system [2,3,12,13].…”

Section: Sarcoidosismentioning

confidence: 99%

The erythropoietin analog ARA 290 for treatment of sarcoidosis-induced chronic neuropathic pain

Swartjes¹,

Heij²,

Brines³

et al. 2012

Expert Opinion on Orphan Drugs

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World Trade Center “Sarcoid-Like” Granulomatous Pulmonary Disease in New York City Fire Department Rescue Workers

Cited by 297 publications

References 33 publications

Novel Murine Model of Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes

Novel Murine Model of Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes

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The erythropoietin analog ARA 290 for treatment of sarcoidosis-induced chronic neuropathic pain

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