Tuberculosis (TB) remains a significant public health challenge in Nigeria, with high morbidity and mortality rates. This statistical overview provides insights into the epidemiology of TB in Nigeria, highlighting regional disparities, demographic factors, and key public health implications. Drawing from referenced studies and World Health Organization reports, the analysis reveals Nigeria's classification as a high TB burden country, with an estimated 460,000 new cases reported annually. The prevalence of TB stands at 616 cases per 100,000 population, with notable regional variations observed across different geographical zones. The findings emphasize the need for multifaceted approaches to TB control, including enhanced surveillance, improved diagnostics, and targeted interventions addressing social determinants of health. By understanding the complex epidemiological landscape of TB in Nigeria, policymakers and public health officials can formulate evidence-based strategies to mitigate disease burden and improve health outcomes for affected populations.