2016
DOI: 10.1111/dote.12513
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Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data

Abstract: SUMMARY To address uncertainty of whether pathologic stage groupings after neoadjuvant therapy (ypTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data—simple descriptions of patient characteristics, cancer categories, and non–risk-adjusted survival—for pathologically staged cancers after neoadjuvant therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using v… Show more

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Cited by 71 publications
(63 citation statements)
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“…These differences were far greater than those seen in patients receiving neoadjuvant therapy. 8 This likely reflects patient selection for neoadjuvant therapy. These differences necessitate risk adjustment in any future analysis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These differences were far greater than those seen in patients receiving neoadjuvant therapy. 8 This likely reflects patient selection for neoadjuvant therapy. These differences necessitate risk adjustment in any future analysis.…”
Section: Discussionmentioning
confidence: 99%
“…However, the role of pure pathologic staging for treatment decision and prognostication for these cancers is waning. 4,8 …”
Section: Discussionmentioning
confidence: 99%
“…Staging of cancer of the esophagus and esophagogastric junction (EGJ), presented in chapter 16 of the 8th edition American Joint Committee on Cancer (AJCC) Cancer Staging Manual (1), was derived from a machine-learning analysis of data from six continents from the Worldwide Esophageal Cancer Collaboration (WECC) (2)(3)(4)(5)(6)(7). The purpose of this manuscript is to review staging in the 8th edition, which now includes clinical (cTNM), pathologic (pTNM), and postneoadjuvant therapy (ypTNM) stage groupings, and examine its application to clinical practice.…”
Section: Introductionmentioning
confidence: 99%
“…Data for this system are derived from patients treated with surgery alone, and the prognostic value of the TNM staging system is limited for patients undergoing neoadjuvant therapy prior to surgery . There are recommendations by the American Joint Committee on Cancer (AJCC) for a neoadjuvant pathological staging system (ypTNM), but these have not yet been appended to the current TNM staging system.…”
Section: Introductionmentioning
confidence: 99%