Worldwide Ethnic Distribution of the G Protein β3 Subunit 825T Allele and Its Association with Obesity in Caucasian, Chinese, and Black African Individuals

Siffert, Winfried; Forster, Peter; Jöckel, Karl‐Heinz; Mvere, D; Brinkmann, B.; Naber, Christoph; Crookes, Robert; Heyns, A. du P.; Epplen, Jörg T.; Fridey, Joy; Freedman, Barry I.; Müller, Norbert; Stolke, D.; Sharma, Arya M.; Moutaery, Khalaf Al; Grosse‐Wilde, H.; Buerbaum, Bettina; Ehrlich, Tanja; Ahmad, Hakimuddin Razi; Horsthemke, Bernhard; Toit, E. D. du; Tiilikainen, A; Ge, Junbo; Wang, Yulin; Yang, Dongliang; Hüsing, Johannes; Rosskopf, Dieter

doi:10.1681/asn.v1091921

Cited by 290 publications

(12 citation statements)

References 39 publications

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“…The maternally active GNB3 gene lowers children's birth weight (Hocher et al, 2000). The low-birth-weight-risk allele has a frequency of 80% in Africans as opposed to 30% in Caucasians (Siffert et al, 1999); hence, this gene can explain a part of the lower birth weight of Black babies.…”

Section: Interracial Children and The Genetic Hypothesismentioning

confidence: 99%

Under the skin: On the impartial treatment of genetic and environmental hypotheses of racial differences.

Rowe¹

2005

American Psychologist

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Environmental and genetic explanations have been given for Black-White racial differences in intelligence and other traits. In science, viable, alternative hypotheses are ideally given equal Bayesian prior weights; but this has not been true in the study of racial differences. This article advocates testing environmental and genetic hypotheses of racial differences as competing hypotheses. Two methods are described: (a) fitting means within structural equation models and (b) predicting means of interracial children. These methods have limitations that call for improved research designs of racial differences. One improvement capitalizes on biotechnology. Genetic admixture estimates--the percentage of genes of European origin that a Black individual possesses (independent of genes related to skin coloration)--can represent genetic influences. The study of interracial children can be improved by increasing sample size and by choosing family members who are most informative for a research question. Eventually, individual-admixture estimates will be replaced by molecular genetic tests of alleles of those genes that influence traits.

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Section: Interracial Children and The Genetic Hypothesismentioning

confidence: 99%

Under the skin: On the impartial treatment of genetic and environmental hypotheses of racial differences.

Rowe¹

2005

American Psychologist

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“…According to the literature 825T allele frequency varies strongly depending on ethnicity and race. Homozygous 825TT genotype was found more often in Africa, where mutant allele frequency varies from 74% to 91% [10]. In Asian populations allele frequency is 46% (42%-55%) on average, in European original population 33% (21%-38%).…”

Section: Resultsmentioning

confidence: 96%

“…This association was also found in most other studies. Siffert W. et al [10] showed that the odds ratio to identify overweight in TT genotype tivity) [16,17], and in some of them this effect was enhanced by adding sibutramine therapy [17,18].…”

Section: Resultsmentioning

confidence: 99%

“…The 825T allele is associated with expression of truncated and functionally active dimer of G protein and increased intracellular signal transduction [6]. Clinical studies showed the association of this polymorphism with susceptibility to obesity and hypertension [7][8][9][10][11][12]. However, the data from different studies are rather contradictory.…”

Section: Introductionmentioning

confidence: 99%

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Frequency of C825T G protein β3 subunit gene polymorphism and its association with obesity in the Kyrgyz population

Mirrakhimov¹,

Olga

Aibek

et al. 2013

family med commun hlth

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Objective: To examine the frequency of C825T G protein β3 subunit gene polymorphism and its association with obesity of ethnic Kyrgyz. Methods:The study enrolled 210 people, 89 patients (35 females, 54 males) with obesity (BMI ≥ 30 kg/m2) and 121 practically healthy patients (38 females, 83 males) with normal body weight and no signs of type 2 diabetes (group of control), who were not observed before by a cardiologist.The blood pressure, anthropometry, glucose and lipid profile were examined among all subjects. Genomic DNA was extracted from peripheral blood cells. G protein β3 subunit C825T polymorphism was determined by polymerase chain reaction (PCR).Results: TT and CT genotypes carriers were grouped together in one group because the TT genotype was rare. CT + TT genotype frequency in the group with obesity made 0.72 and was significantly higher than that in the control group -0.52 (χ2-8.44; P = 0.004; odds ratio -2.55; 95%CI 1.31-4.23). The statistical analysis revealed that hypertension (45% vs. 31.3%, P = 0.049) and obesity (51.2% vs. 30%, P <0.01) occurred significantly more often in CT + TT genotype carriers than in the CC homozygotes. The results of the multivariate logistic regression analysis showed that the presence of 825T allele (exp β -2.89; 95% CI 1.25-6.7; P=0.013), along with the occasional consumption of vegetables (exp β -3.47; 95% CI 1.52-7.94; P=0.003) was the significant risk factor for obesity, regardless of gender, age and level of physical activity. In the construction of the similar regression model for hypertension, the statistically significant role of 825T allele was lost after adjustment for obesity as an independent variable. Conclusion:G protein β3 subunit gene C825T allele in the Kyrgyz ethnic group has an association with obesity.

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“…The 825C > T SNP in the gene of the G-protein β3 subunit ( GNB3 ) has been linked to metabolic features such as hypertension, atherosclerosis and immunological response. The T-allele has also been associated with obesity risk in German, Chinese and South African populations ( Siffert et al, 1999 ). In pregnant women, carriers of the risk allele have a higher weight gain during gestation ( Dishy et al, 2003 ).…”

Section: Genetic Factors Associated With Gestational Diabetes Mellitu...mentioning

confidence: 99%

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus

et al. 2022

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Gestational Diabetes Mellitus (GDM) is a highly prevalent maternal pathology characterized by maternal glucose intolerance during pregnancy that is, associated with severe complications for both mother and offspring. Several risk factors have been related to GDM; one of the most important among them is genetic predisposition. Numerous single nucleotide polymorphisms (SNPs) in genes that act at different levels on various tissues, could cause changes in the expression levels and activity of proteins, which result in glucose and insulin metabolism dysfunction. In this review, we describe various SNPs; which according to literature, increase the risk of developing GDM. These SNPs include: (1) those associated with transcription factors that regulate insulin production and excretion, such as rs7903146 (TCF7L2) and rs5015480 (HHEX); (2) others that cause a decrease in protective hormones against insulin resistance such as rs2241766 (ADIPOQ) and rs6257 (SHBG); (3) SNPs that cause modifications in membrane proteins, generating dysfunction in insulin signaling or cell transport in the case of rs5443 (GNB3) and rs2237892 (KCNQ1); (4) those associated with enzymes such as rs225014 (DIO2) and rs9939609 (FTO) which cause an impaired metabolism, resulting in an insulin resistance state; and (5) other polymorphisms, those are associated with growth factors such as rs2146323 (VEGFA) and rs755622 (MIF) which could cause changes in the expression levels of these proteins, producing endothelial dysfunction and an increase of pro-inflammatory cytokines, characteristic on GDM. While the pathophysiological mechanism is unclear, this review describes various potential effects of these polymorphisms on the predisposition to develop GDM.

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Worldwide Ethnic Distribution of the G Protein β3 Subunit 825T Allele and Its Association with Obesity in Caucasian, Chinese, and Black African Individuals

Cited by 290 publications

References 39 publications

Under the skin: On the impartial treatment of genetic and environmental hypotheses of racial differences.

Under the skin: On the impartial treatment of genetic and environmental hypotheses of racial differences.

Frequency of C825T G protein β3 subunit gene polymorphism and its association with obesity in the Kyrgyz population

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus

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