Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinoma

Pujol, Flor H.; Navas, María Cristina; Hainaut, Pierre; Chemin, Isabelle

doi:10.1016/j.canlet.2009.07.013

Cited by 70 publications

(62 citation statements)

References 71 publications

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“…37,38 Genotype D is the most common genotype in HBVassociated HCC as reported from different series. 39 The b-catenin pathway appears not to be significantly involved in HBV-related HCC in India. The very low frequency of TP53 mutation suggests low levels of Aflatoxin B1 exposure.…”

Section: Are Indians Genetically More Prone To Hepatocellular Carcinoma?mentioning

confidence: 95%

Risk Factors for Hepatocellular Carcinoma in India

Kar

2014

Journal of Clinical and Experimental Hepatology

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Hepatocellular carcinoma (HCC) is an important cause of death all over the world, more so in Asia and Africa. The representative data on epidemiology of HCC in India is very scanty and cancer is not a reportable disease in India and the cancer registries in India are mostly urban. 45 million people who are suffering from chronic Hepatitis B virus (HBV) infection and approximately 15 million people who are afflicted with chronic Hepatitis C virus (HCV) infection in India. HBV and HCV infection is considered an important etiologic factor in HCC. Positive association between HCC and consumption of alcohol where alcohol contribute as a cofactor for hepatotoxins and hepatitis viruses. Aflatoxin contamination in the diets, Hepatitis B virus infection and liver cirrhosis in Andhra Pradesh, India and direct chronic exposure to aflatoxins was shown to cause liver cirrhosis. Cirrhosis of liver of any cause lead to develop about 70%-90% of HCC. Aflatoxin interact synergistically with Hepatitis B virus (HBV)/Hepatitis C virus (HCV) infection which increase the risk of HCC. HBV infection, HBV infection with Aflatoxin exposure, viral infection and alcohol consumption leading to overt cirrhosis of the liver, alcohol consumption leading to cirrhosis of the liver with viral infection are the predominant risk factor for the development of HCC. HCV and alcohol are also associated with HCC in India. Indians develop diabetes at younger age, Asians have strong genetic susceptibility for type II diabetes. Diabetes mellitus is identified as a risk factor for HCC. Prevention of viral infection by universal vaccination against hepatitis virus, HCC surveillance program, preventing alcoholic liver diseases, fungal contamination of grains and ground crops to prevent basically Aflatoxin exposure are important measures to prevent liver diseases and HCC among those at risk. ( J CLIN EXP HEPATOL 2014;4:S34-S42)

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Section: Are Indians Genetically More Prone To Hepatocellular Carcinoma?mentioning

confidence: 95%

Risk Factors for Hepatocellular Carcinoma in India

Kar

2014

Journal of Clinical and Experimental Hepatology

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“…Of the eight genotypes discovered, genotypes B and C are prevalent in Asia, while genotypes A and D are prevalent in Europe, United States and Central Africa (Pujol et al, 2009). Four genotypes have been observed in China mainland and genotype B and C accounts for 95%.…”

Section: Hepatitis Viral Infectionmentioning

confidence: 99%

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Gao¹,

Xie²,

Yang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

127

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“…HBV genotype F was associated to a higher frequency of HCC development at younger age in Alaskan individuals (Livingston et al, 2007). However, the risk of HCC may differ among subgenotypes (Pujol et al, 2009). Fig.…”

Section: Hbvmentioning

confidence: 85%

“…The selection of the G1896A seems to be genotype-dependent (Devesa & Pujol, 2007). The basal core promoter overlaps with the X region of the HBV genome, and mutations in the amino acid sequences at positions 130 and 131 in this region (K130M and V131I) has been proposed as prognostic markers for the development of liver cancer (Kuang et al, 2004, Pujol et al, 2009). Some genotypic variability may also occur in terms of interferon sensitivity and development of drug resistance Ramos et al, 2007).…”

Section: Hbvmentioning

confidence: 99%