Worldwide prevalence and genotype distribution of human astrovirus in gastroenteritis patients: A systematic review and meta-analysis

Farahmand, Mohammad; Khales, Pegah; Salavatiha, Zahra; Sabaei, Milad; Hamidzade, Malihe; Aminpanah, Danesh; Tavakoli, Ahmad

doi:10.1016/j.micpath.2023.106209

Cited by 5 publications

(1 citation statement)

References 252 publications

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“…Children are the typical culprits of this virus, especially children younger than 5 years old. 2 This virus is transmitted fecal-orally and the classic presenting symptoms are non-bloody watery diarrhea of 2-4 days duration with occasional association with episodes of vomiting as well as headaches, abdominal pain, and fevers. Although an infrequent and self-limiting cause of gastroenteritis in children, Astroviridae has not been often described as a cause of enteritis in the solid organ transplant (SOT) population, as in the present case.…”

Section: Discussionmentioning

confidence: 99%

Underrecognized cause diarrhea in solid organ transplant: a report of astroviridae enteritis in liver transplant

Wilson,

Rosenstengle,

Spak

2024

Transplant Infectious Dis

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We present a case of a 72‐year‐old liver transplant recipient 7 years prior who presents to our hospital with general malaise, fatigue, low‐grade fevers, and watery diarrhea. He was found to have Astrovirus via PCR testing in a comprehensive stool panel. The patient's home mycophenolic acid was held upon admission, while cyclosporine was continued through his hospital stay. Generally, Astroviridae infection is a rarely identified cause of enteritis and even less so in the transplant population. Although reports have been published regarding devastating cases of encephalitis in immunocompromised patients, our patient did not exhibit these symptoms and draws into question the danger of this virus in other immunosuppressed populations. This case helps to better elucidate which patient populations should be approached with caution in the setting of Astroviridae infection.

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Section: Discussionmentioning

confidence: 99%

Underrecognized cause diarrhea in solid organ transplant: a report of astroviridae enteritis in liver transplant

Wilson,

Rosenstengle,

Spak

2024

Transplant Infectious Dis

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Understanding neurotropic enteric viruses: routes of infection and mechanisms of attenuation

Lulla,

Sridhar

2024

Cell. Mol. Life Sci.

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The intricate connection between the gut and the brain involves multiple routes. Several viral families begin their infection cycle in the intestinal tract. However, amongst the long list of viral intestinal pathogens, picornaviruses, and astroviruses stand out for their ability to transition from the intestinal epithelia to central or peripheral nervous system cells. In immunocompromised, neonates and young children, these viral infections can manifest as severe diseases, such as encephalitis, meningitis, and acute flaccid paralysis. What confers this remarkable plasticity and makes them efficient in infecting cells of the gut and the brain axes? Here, we review the current understanding of the virus infection along the gut-brain axis for some enteric viruses and discuss the molecular mechanisms of their attenuation.

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Molecular characterization of human astrovirus infection in children under 5 years of age with acute gastroenteritis in Tehran, Iran, 2021–2022: co-infection with rotavirus

Kachooei,

Mirhoseinian,

Jalilvand

et al. 2024

Virus Genes

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Worldwide prevalence and genotype distribution of human astrovirus in gastroenteritis patients: A systematic review and meta-analysis

Cited by 5 publications

References 252 publications

Underrecognized cause diarrhea in solid organ transplant: a report of astroviridae enteritis in liver transplant

Underrecognized cause diarrhea in solid organ transplant: a report of astroviridae enteritis in liver transplant

Understanding neurotropic enteric viruses: routes of infection and mechanisms of attenuation

Molecular characterization of human astrovirus infection in children under 5 years of age with acute gastroenteritis in Tehran, Iran, 2021–2022: co-infection with rotavirus

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