Worldwide prevalence of hypospadias

Springer, Alexander; Heijkant, M. van den; Baumann, Suzann

doi:10.1016/j.jpurol.2015.12.002

Cited by 213 publications

(124 citation statements)

References 28 publications

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“…This trend was first detected in the late 60s, 10 then later in Hungary and the United Kingdom, 11,12 followed by Oceania, North America 13,14 and the Scandinavian countries. 2,15 Exposure to endocrine disrupting chemicals, 16 changes in the maternal age repartition, or increased surgical success with hypospadiac boys reaching paternity themselves, 17 may all be contributing factors. These data have nevertheless been questioned.…”

Section: Epidemiologymentioning

confidence: 99%

Molecular genetics of hypospadias and cryptorchidism recent developments

et al. 2018

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During the last decade, a tremendous amount of work has been devoted to the study of the molecular genetics of isolated hypospadias and cryptorchidism, two minor forms of disorders of sex development (DSD). Beyond the genes involved in gonadal determination and sex differentiation, including those underlying androgen biosynthesis and signaling, new genes have been identified through genome-wide association study and familial clustering. Even if no single genetic defect can explain the whole spectrum of DSD, these recent studies reinforce the strong role of the genetic background in the occurrence of these defects. The timing of signaling disruption may explain the different phenotypes.

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Section: Epidemiologymentioning

confidence: 99%

Molecular genetics of hypospadias and cryptorchidism recent developments

et al. 2018

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“…The reported incidence is 0.2% to 1% . However, a recent review of the literature regarding the worldwide prevalence of hypospadias reported geographic, regional, and ethnic differences, with an extreme heterogeneity of published studies and contradictory reports on rising hypospadias rates …”

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confidence: 99%

Prenatal Anogenital Distance Is Shorter in Fetuses With Hypospadias

et al. 2016

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“…§Incidence (per 100 000) and mortality (per 100 000) of renal cell carcinoma from Znaor et al . ¶Incidence of hypospadias (per 10 000 birth); Japan from Kurahashi et al ., USA from Springer et al . ††Prevalence of stone disease; Japan from Yasui et al ., USA from Scales et al .…”

Section: Discussionmentioning

confidence: 99%

Current work environments: What problems are being faced by Japanese urologists?

2018

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Computer technology has contributed to innovative progress in industrial infrastructures and has had a major influence on various work environments. Evaluations of work environments are routinely carried out in Western countries, but historically there has been resistance to such evaluations in Japan. In this mini-review, we discuss the current work environments of urologists in Japan. The number of urologists has increased each year, and the population density of urologists was 5.4 (per 100 000 people) in 2014. The average age of urologists in Japan was 48.9 years, and the percentage of female urologists was just 5.3%. Additionally, the geographic distribution of urologists was uneven in Japan. From projections based on population dynamics, the need for more urologists in the near future will probably increase. Because medical environments vary depending on the country, it is necessary to understand current work environments in greater detail initially. Furthermore, we should determine original measures for the establishment of satisfactory urological work environments in Japan.

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Worldwide prevalence of hypospadias

Cited by 213 publications

References 28 publications

Molecular genetics of hypospadias and cryptorchidism recent developments

Molecular genetics of hypospadias and cryptorchidism recent developments

Prenatal Anogenital Distance Is Shorter in Fetuses With Hypospadias

Current work environments: What problems are being faced by Japanese urologists?

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