Worldwide Research Trends on Medicinal Plants

Alcayde, Alfredo; Garrido-Cárdenas, José Antonio; Manzano‐Agugliaro, Francisco

doi:10.3390/ijerph17103376

Cited by 312 publications

(176 citation statements)

References 75 publications

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“…A recent bibliometric study of all works listed in the Scopus database until 2019 (analysis of more than 100,000 publications) has underlined that global research is focused more on bioprospection rather than cultivation or domestication of plants with known biological potential [ 4 ]. This could pose a threat to the future of these natural resources.…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Karous

Jilani

Ghrabi-Gammar

2021

Plants

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Thanks to its geographic location between two bioclimatic belts (arid and Saharan) and the ancestral nomadic roots of its inhabitants, the sector of Ouled Dabbeb (Southern Tunisia) represents a rich source of plant biodiversity and wide ranging of ethnobotanical knowledge. This work aims to (1) explore and compile the unique diversity of floristic and ethnobotanical information on different folk use of plants in this sector and (2) provide a novel insight into the degree of knowledge transmission between the current population and their semi-nomadic forefathers. Ethnobotanical interviews and vegetation inventories were undertaken during 2014–2019. Thirty informants aged from 27 to 84 were interviewed. The ethnobotanical study revealed that the local community of Ouled Dabbeb perceived the use of 70 plant species belonging to 59 genera from 31 families for therapeutic (83%), food (49%), domestic (15%), ethnoveterinary (12%), cosmetic (5%), and ritual purposes (3%). Moreover, they were knowledgeable about the toxicity of eight taxa. Nearly 73% of reported ethnospecies were freely gathered from the wild. The most commonly used plant parts were leaves (41%) followed by flowers and inflorescence (16%). We reported the use and collection of non-renewable parts (underground storage organs and roots) for 20 ethnospecies. Interestingly, a comparison with the available literature in Tunisia and neighboring countries reveals 13 new useful plants as well as 17 plants with new uses and demonstrates an important reservoir of traditional ethnobotanical heritage that is still sustained by respondents stemming from the semi-nomadic lifestyle of their ancestors (74% of cited taxa). These data could set a basis for further phytochemical and pharmacological research and conservative approach of the most relevant plant species including endemic overused and endangered taxa.

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Section: Introductionmentioning

confidence: 99%

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Karous

Jilani

Ghrabi-Gammar

2021

Plants

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“…The use of medicinal plants globally continues to grow [15]. It is not only an issue in lower-income countries due to the lack of accessibility to the orthodox health care system but also in middle and highincome countries, its use is considered prestigious where the medical plant has been well researched and tested [4].…”

Section: Discussionmentioning

confidence: 99%

Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model

Asare

Ongong'a

Anang

et al. 2020

Preprint

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Background Croton membranaceus Müll.Arg., root extract has been scientifically and clinically proven to be efficacious in the management of BPH. However, its effect on liver drug-metabolizing enzymes has not been established. This study aimed to determine the effect of the plant extract on phase I and phase II drug-metabolizing enzymes. Materials and methods Fifteen (15) castrated testosterone-induce BPH male Albino Wister rats weighing between 120–150 grams were randomly divided into 3 groups of 5 rats each (Groups II-IV). Five (5) uncastrated rats in Group I was used as a negative control, receiving only distilled water. Group II was administered 30 mg/kg b. wt extracts of C. membranaceus. Group III was the BPH-model group (administered distilled water) while Group IV was administered 0.5 mg/kg b. wt finasteride and was used as the positive control. BPH was induced in groups II-IV by administering testosterone propionate, 3 mg/kg b. wt for 28 days after a 7-day post castration rest period. Rats were euthanized and individual livers harvested for microsome preparation. The liver microsomes were assayed for, Phase I Drug Metabolizing Enzymes (DME); CYP1A2, CYP3A4, CYP2D6, and phase II; GST-M1 using Enzyme-Linked Immuno-Sorbent Assay (ELISA) techniques. Results Significant induction in phase I enzymes CYP1A2 was observed (p = 0.02), while CYP3A4 and CYP2D6 were inhibited (0.00, 0.01, respectively). Phase II enzymes, GSTM1, showed a significant induced (p = 0.01). C.membranaceus induced CYP1A2 strongly, GSTM1 modestly, and had an inhibitory effect on CYP3A4/CYP2D6. Conclusion Croton membranaceus induces and inhibits some phase I metabolizing enzymes while moderately inducing phase II metabolizing enzymes. Care should be taken in the use of phytotherapy in conjunction with other drugs.

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“…Traditional medicine, who quality, security and efficiency are undeniable (Salmerón-Manzano et al, 2020;Orch et al, 2015;Abouri et al, 2012;Nkongmeneck, 2007), also contribute in the realisation of the universal objective of easy access to healthcare. Its efficiency stems from the fact that it is less expensive and really effective (Ouhaddou et al, 2014;WHO, 1978;.…”

Section: Introductionmentioning

confidence: 99%

The Use of NTFPs in the Baka and Kounabembe Traditional Pharmacopoeia in the Northern Periphery of the Boumba-Bek National Park (Southeastern Cameroon)

2021

JBAH

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Forest conservation around protected areas includes among others sustainable management of natural resources. This study was conducted in the area of the northern outskirts of the Boumba-Bek National Park in order to evaluate the potential use of plants in traditional medicine. Ethnobotanical surveys were conducted with local people using AFLORA survey forms. A total of 132 plant species used in traditional medicine for primary health care were identified. These plants belong to 109 genera and 45 families. 224 treatments for 101 disease symptoms were collected. These diseases include the nervous system, excretory system and nutritional function. The most recurrent diseases are cough, sexual weakness, back pain, abscess, general tiredness, malaria. Some plants such as Baillonella toxisperma, Alstonia boonei, Annonidium mannii, Ricinidendron heudelotii, Klainedoxa gabonensis, Scorodophloeus zenkeri, Swartzia sp. treat several diseases at once. The plant parts mostly used are stem bark, leaves, seeds, sap, the marrow of the bark, the pith of the stem. The main method of preparation of these recipes is decoction while the most common method of administration is oral administration. The plant resources of this village have a high potential in traditional medicine for primary health care. The importance index varied from plant to plant.

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Worldwide Research Trends on Medicinal Plants

Cited by 312 publications

References 75 publications

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model

The Use of NTFPs in the Baka and Kounabembe Traditional Pharmacopoeia in the Northern Periphery of the Boumba-Bek National Park (Southeastern Cameroon)

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