“…This idea is particularly applicable to anorexia nervosa (AN), a devastating condition with the highest mortality rate of any psychiatric illness (Harris and Barraclough, 1998). AN is associated with somatic preoccupation with visceral gut sensations (eg, fullness; Perez et al, 2013), as well as heightened fear and anxious rumination (Frank et al, 2012;Startup et al, 2013), and enduring anxiety-related personality traits such as harm avoidance (Brewerton et al, 1993;Fassino et al, 2002). Because of this, influential theoretical accounts about the neurobiology of AN have recently highlighted the likely role of interoceptive regions in the insula in the pathophysiology of the disorder (Kaye et al, 2009(Kaye et al, , 2013Nunn et al, 2011).…”