Would Cutibacterium acnes Be the Villain for the Chronicity of Low Back Pain in Degenerative Disc Disease? Preliminary Results of an Analytical Cohort

Rocha, Vinícius Magno da; Lima, Carla Ormundo Gonçalves Ximenes; Candido, Gustavo Baptista; Cassiano, Keila Mara; Lewandrowski, Kai‐Uwe; Ferreira, Eliane de Oliveira; Fiorelli, Rossano Kepler Alvim

doi:10.3390/jpm13040598

Cited by 4 publications

(1 citation statement)

References 58 publications

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“…Такі зміни, за популяційної поширеності для поперекового відділу хребта на рівні ~6 % [52], гіпотетично так чи інакше пов'язані з патологією міжхребцевих дисків (див. [3,30,65]), можливо і через запальну ланку, обумовлену колонізацією ушкодженого міжхребцевого диску коменсальною бактерією Cutibacterium acnes [3,4,18,30,33,44,53,62,63] (дискусія: [9,16,47,65], [25] і [32], [10] і [31]). У якості можливого додаткового фактору ризику болю у спині розглядають поширені серед дорослих дефекти добре іннервованих замикальних пластинок хребців (англ.…”

Section: другий клас включає патоморфологічні/патофізіологічні терміниunclassified

Degenerative Intervertebral Disc Disease: Difficulties in Definition of the Concept and Epidemiology of the Phenomenon. Brief Communication

Medvediev,

Marushchenko,

Tsymbaliuk

2023

Clin. and prev. med.

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The aim. The significant prevalence of intervertebral discs chronic pathology in the human population against the background of the lack of a clear and unified definition of the concept of «degenerative [intervertebral] disc disease» (DDD) creates difficulties in the study and formation of treatment protocols for this pathology. This study aims to clarify the epidemiological characteristics and terminological features of the pathology of the intervertebral discs covered by the term «DDD». Materials and methods. A systematic search in pubmed and related scientific and professional databases for publications devoted to DDD’s terminological features and epidemiology was conducted. In the analysis, the papers in which DDD and semantically related concepts and clinical phenomena are included as the primary research objects. Results. Based on the analysis, it is found that there is no unified defining the concept of DDD, which includes both initial degenerative changes in the disc, regardless of the manifestation of the pain syndrome, and conditions with a clear pathomorphological picture, such as intervertebral disc herniation, degenerative spinal stenosis, etc. DDD is pathophysiological and conventional; its list of pathomorphological and clinical correlates still needs to be completed. Clinical phenomena, considered the most certain correlates of DDD, can be caused by other pathological processes. Currently, the only but somewhat inaccurate indicator of the prevalence of back pain in the human population is the epidemiological characteristic of back pain, which, according to available calculations, can reach 800 million people at any given time, i.e., 10 % of the human population. Uncertainty regarding the semantics of the term DDD makes it challenging to unify research results and develop effective clinical protocols. Conclusions. The meaning of the term DDD remains unclear and non-unified, and the epidemiological characteristics of the phenomenon of back pain can only be used with significant caution for a rough estimate of the prevalence of clinically significant forms of ddd. Unifying and clarifying terminology, prevalence, and identification of benchmark etiological factors of DDD will allow to improve treatment protocols for this pathology and improve its results.

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Section: другий клас включає патоморфологічні/патофізіологічні терміниunclassified

Degenerative Intervertebral Disc Disease: Difficulties in Definition of the Concept and Epidemiology of the Phenomenon. Brief Communication

Medvediev,

Marushchenko,

Tsymbaliuk

2023

Clin. and prev. med.

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Risk factors associated with low-grade virulent infection in intervertebral disc degeneration: a systematic review and meta-analysis

Zhang,

Jia,

Deng

et al. 2024

The Spine Journal

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Expression of toll-like receptors in cartilage endplates cells: a role of toll-like receptor 2 in pro-inflammatory and -catabolic gene expression

Mengis,

Bernhard,

Herger

et al. 2024

Preprint

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Introduction The vertebral cartilage endplate (CEP), essential for intervertebral disc health, is susceptible to degeneration, which can be associated with chronic low back pain, disc degeneration, and Modic changes. Although it has been established that intervertebral disc cells express toll-like receptors (TLRs), which can recognize diverse pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), triggering an immune response, it is unknown whether CEP cells (CEPC) share this trait. The CEP exhibits a significantly higher cell density compared to the disc, potentially heightening the relevance of CEPC in this context. This study aimed to identify TLRs on CEPC and explore their role in activating pro-inflammatory and catabolic gene expression. Methods Gene expression of TLR1-10 was measured with quantitative real-time polymerase chain reaction in human CEPs and expanded CEPC. Additionally, CEPC were stimulated with tumor necrosis factor alpha and interleukin 1 beta, specific TLR2/6, TLR2/1 and TLR4 agonist (Pam2csk4, Pam3csk4 and lipopolysaccharide) and with the 30 kDa N-terminal fibronectin fragment, a representative DAMP. TLR2 signaling was inhibited with TL2-C29. TLR2 protein expression was measured with flow cytometry. Results An ex-vivo analysis of CEP tissue found all 10 TLRs expressed while cultured CEPC lost TLR7 and TLR8 expression. TLR2 was the only TLR whose expression significantly increased after pro-inflammatory stimulation. Stimulation of the TLR2/6 heterodimer with Pam2csk4 upregulated TLR2 protein expression. After 48 hours of stimulation, all applied ligands upregulated expression of pro-inflammatory genes and the matrix metalloproteases 1 (MMP1), MMP3, and MMP13. TLR2 inhibition was able to specifically inhibit the upregulated genes. Conclusion The expression of TLR1-10 in CEPC indicates that the CEP is susceptible to PAMP and DAMP stimulation. TLR2 expression in CEPC is enhanced under inflammatory conditions and its stimulation has pro-inflammatory and pro-catabolic consequences. Therefore, TLR2 signaling in CEPC might play an important role in disc degeneration and Modic changes.

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Would Cutibacterium acnes Be the Villain for the Chronicity of Low Back Pain in Degenerative Disc Disease? Preliminary Results of an Analytical Cohort

Cited by 4 publications

References 58 publications

Degenerative Intervertebral Disc Disease: Difficulties in Definition of the Concept and Epidemiology of the Phenomenon. Brief Communication

Degenerative Intervertebral Disc Disease: Difficulties in Definition of the Concept and Epidemiology of the Phenomenon. Brief Communication

Risk factors associated with low-grade virulent infection in intervertebral disc degeneration: a systematic review and meta-analysis

Expression of toll-like receptors in cartilage endplates cells: a role of toll-like receptor 2 in pro-inflammatory and -catabolic gene expression

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