Would sickle cell trait influence the metabolic control in sub‐Saharan individuals with type 2 diabetes?

Ama, Vicky Jocelyne Moor; Kengne, André Pascal; Nansseu, N. J. R.; Nouthe, Brice; Sobngwi, Eugène

doi:10.1111/j.1464-5491.2012.03620.x

Cited by 10 publications

(10 citation statements)

References 12 publications

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“…This is in contrast to another study among Africans, which did not find any association between type 2 diabetes mellitus (T2D) and SCT. The study observed that the prevalence of 19% for SCT among the patients is comparable with the prevalence in the general population [13] . Another study in African Americans concluded that SCT does not increase the risk of microvascular complications.…”

Section: Type 2 Diabetes Mellitussupporting

confidence: 55%

“…Nigeria probably has the highest number of people with the trait, not just because of its high population but also because of a high prevalence of 25-30% [9] . The distributions in other parts of Africa are between 10-15% for Liberia, Ghana and Uganda [10][11][12] , respectively, Cameroon and the Republic of Gabon, a central African country, have a prevalence of 19 and 22%, respectively, closer to the prevalence in Nigeria than to other African countries [13,14] . Review of data from two decades of newborn screening in the United States revealed a prevalence of 1.5% [15] , but the prevalence in African Americans is about 8% [16] , which is similar to that of other African populations who migrated out of Africa as a result of the slave trade.…”

Section: Epidemiologymentioning

confidence: 99%

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Sickle Cell Trait: A Benign State?

Kotila

2016

Acta Haematol

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Background: Sickle cell trait (SCT) is the heterozygous form of sickle cell disease and expectedly should be a benign state with no complications ascribed to it. There are numerous reports challenging its being a benign condition, though this is controversial. Methods and Results: A review of the results of the accompanying investigations done on some of the patients show that beta thalassemia may be responsible for many of the ascribed symptoms and complications. These patients may therefore have sickle cell beta thalassemia, a compound heterozygous form of sickle cell disease. Conclusion: It is important to screen for beta thalassemia using red cell indices and quantitation of the different hemoglobin fractions before attributing any symptoms to SCT. DNA analysis, though useful in ascertaining the presence of the sickle cell gene, is not sufficient. There is the need to exclude the presence of mutations for beta thalassemia, which often is geographical region-specific.

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Section: Type 2 Diabetes Mellitussupporting

confidence: 55%

Section: Epidemiologymentioning

confidence: 99%

Sickle Cell Trait: A Benign State?

Kotila

2016

Acta Haematol

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“…A recent study from Cameroon has provided findings suggesting similar frequencies of sickle cell trait (SCT) in people with diabetes and in the general population,42 and that the presence of SCT did not affect the metabolic control of diabetes. A striking fact in this study, however, was the older age of patients with SCT, for a comparable duration of diagnosed diabetes with the non-trait patients, indicating a possible late onset of type 2 diabetes in SCT carriers.…”

Section: Concurrent and Comorbidities Of Diabetes In Africamentioning

confidence: 99%

“…Clarifying a possible link between SCT and diabetes onset or early attrition in diabetes is important in Africa, where the largest number of people with SCT and sickle cell disease (SCD) are found. The growing population with diabetes in Africa will likely include more people with both diabetes and SCT/SCD, and may result in differential features of diabetes across the continent, since the majority of those with SCT/SCD are typically found in Equatorial Africa, the epicentre of the disease 42. Resolving this uncertainty may invite efforts beyond what a single country can achieve.…”

Section: Concurrent and Comorbidities Of Diabetes In Africamentioning

confidence: 99%

New insights on diabetes mellitus and obesity in Africa–Part 1: prevalence, pathogenesis and comorbidities

Kengne

Echouffo‐Tcheugui

Sobngwi

et al. 2013

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Evidence continues to accumulate on the rising burden of diabetes mellitus at a higher pace in Africa. In a series of two papers, we sought to summarise recent evidence on diabetes and obesity in Africa based on a systematic review of studies published between January 2002 and October 2012. This first paper on the prevalence, pathogenesis and comorbidities shows that the increase in diabetes prevalence has paralleled that of obesity in Africa. Recent surveys on diabetes and obesity have been largely suboptimal. Hence, the need for more representative and robust continent-wide prevalence figures, which may be somehow achieved through pooling of existing data. Prospective studies linking environmental risk factors to disease occurrence and outcomes remain scarce, and genetic factors for diabetes or obesity have not been extensively assessed. The health consequences of diabetes are manifold, and include a complex interaction with other conditions like HIV infection and sickle cell disease/trait.

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“…Liberia, Ghana and Uganda have 10–15% of their population being carriers of haemoglobin S gene [13, 15, 16]. Cameroon and Gabon have haemoglobin S gene prevalence of 19 and 22%, respectively [17, 18]. SCT individuals are clinically healthy to donate blood [19].…”

Section: Introductionmentioning

confidence: 99%

Storage related haematological and biochemical changes in Plasmodium falciparum infected and sickle cell trait donor blood

et al. 2018

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BackgroundIn sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities. The haemato-biochemical properties of SCT and asymptomatic malaria in donor blood have not been evaluated. This study evaluated the haemato-biochemical impact of SCT and asymptomatic malaria infections in citrate-phosphate-dextrose-adenine (CPDA-1) stored donor blood units.MethodsFifty-milliliters of sterile CPDA-1 anti-coagulated blood were drained into the sample pouch attached to the main blood bag. Ten units each of sickle cell/malaria negative, sickle cell and malaria positive blood were analyzed. Baseline and weekly haematological profiling and week 1, 3 and 5 concentrations of plasma haemoglobin, % haemolysis, sodium, potassium and chloride and lactate dehydrogenase (LDH) were assayed. Differences between baseline and weekly data were determined using one-way analysis of variance (ANOVA) and Kruskal-Wallis test, whereas differences between baseline parameters and week 1–3 data pairs were determined using paired t-test. P-value < 0.05 was considered statistically significant.ResultsStorage of SCT and malaria infected blood affected all haematological cell lines. In the SCT donors, red blood cells (RBC) (4.75 × 1012/L ± 1.43baseline to 3.49 × 1012/L ± 1.09week-5), haemoglobin (14.45 g/dl ± 1.63baseline to 11.43 g/dl ± 1.69week-5) and haematocrit (39.96% ± 3.18baseline to 33.22% ± 4.12week-5) were reduced. In the asymptomatic malaria group, reductions were observed in RBC (5.00 × 1012/L ± 0.75baseline to 3.72 × 1012/L ± 0.71week-5), haemoglobin (14.73 g/dl ± 1.67baseline to 11.53 g/dl ± 1.62week-5), haematocrit (42.72% ± 5.16baseline to 33.38% ± 5.80week-5), mean cell haemoglobin concentration (35.48 g/dl ± 1.84baseline to 35.01 g/dl ± 0.64week-5) and red cell distribution width coefficient of variation (14.81% ± 1.54baseline to 16.26% ± 1.37week-5). Biochemically, whereas plasma LDH levels significantly increased in asymptomatic malaria blood donors (319% increase at week 5 compared to baseline), SCT blood donors had the most significant increase in plasma potassium levels at week 5 (382% increase). Sodium ions significantly reduced in SCT/malaria negative and sickle cell trait blood at an average rate of 0.21 mmol/L per day. Moreover, elevations in lymphocytes-to-eosinophils and lymphocytes-to-neutrophils ratios were associated with SCT and malaria positive blood whilst elevation lymphocytes-to-basophils ratio was exclusive to malaria positive blood.ConclusionSevere storage lesions were significant in SCT or malaria positive donor blood units. Proper clinical evaluation must be done in prospective blood donors to ensure deferral of such donors.Electronic supplementary materialThe online version of this article (10.1186/s12878-018-0128-x) contains supplementary material, which is available to authorized users.

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Would sickle cell trait influence the metabolic control in sub‐Saharan individuals with type 2 diabetes?

Cited by 10 publications

References 12 publications

Sickle Cell Trait: A Benign State?

Sickle Cell Trait: A Benign State?

New insights on diabetes mellitus and obesity in Africa–Part 1: prevalence, pathogenesis and comorbidities

Storage related haematological and biochemical changes in Plasmodium falciparum infected and sickle cell trait donor blood

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